Literature DB >> 28139654

CPEB4 links the clock and the UPR to protect the liver.

Paul C Moore1, Scott A Oakes1.   

Abstract

Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28139654      PMCID： PMC5555618          DOI： 10.1038/ncb3460

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

Review 1.  The unfolding tale of the unfolded protein response.

Authors:  Y Ma; L M Hendershot
Journal:  Cell       Date:  2001-12-28       Impact factor: 41.582

Review 2.  A review of the mammalian unfolded protein response.

Authors:  Anirikh Chakrabarti; Aaron W Chen; Jeffrey D Varner
Journal:  Biotechnol Bioeng       Date:  2011-08-09       Impact factor: 4.530

3.  Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression.

Authors:  Shihoko Kojima; Elaine L Sher-Chen; Carla B Green
Journal:  Genes Dev       Date:  2012-12-15       Impact factor: 11.361

4.  cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.

Authors:  Satoru Koyanagi; Ahmed M Hamdan; Michiko Horiguchi; Naoki Kusunose; Akinori Okamoto; Naoya Matsunaga; Shigehiro Ohdo
Journal:  J Biol Chem       Date:  2011-07-18       Impact factor: 5.157

5.  Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver.

Authors:  Gaspard Cretenet; Mikaël Le Clech; Frédéric Gachon
Journal:  Cell Metab       Date:  2010-01       Impact factor: 27.287

6.  Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.

Authors:  Charity Atkins; Qi Liu; Elisabeth Minthorn; Shu-Yun Zhang; David J Figueroa; Katherine Moss; Thomas B Stanley; Brent Sanders; Aaron Goetz; Nathan Gaul; Anthony E Choudhry; Hasan Alsaid; Beat M Jucker; Jeffrey M Axten; Rakesh Kumar
Journal:  Cancer Res       Date:  2013-01-18       Impact factor: 12.701

Review 7.  Endoplasmic reticulum proteostasis in hepatic steatosis.

Authors:  Andrei Baiceanu; Pierre Mesdom; Marie Lagouge; Fabienne Foufelle
Journal:  Nat Rev Endocrinol       Date:  2016-08-12       Impact factor: 43.330

8.  A novel link between circadian clocks and adipose tissue energy metabolism.

Authors:  Jun Yoshino; Samuel Klein
Journal:  Diabetes       Date:  2013-07       Impact factor: 9.461

9.  UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

Authors:  D Thomas Rutkowski; Jun Wu; Sung-Hoon Back; Michael U Callaghan; Sean P Ferris; Jahangir Iqbal; Robert Clark; Hongzhi Miao; Justin R Hassler; Jamie Fornek; Michael G Katze; M Mahmood Hussain; Benbo Song; Jayanth Swathirajan; Junying Wang; Grace D-Y Yau; Randal J Kaufman
Journal:  Dev Cell       Date:  2008-12       Impact factor: 12.270

10.  Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.

Authors:  Julie A Moreno; Mark Halliday; Colin Molloy; Helois Radford; Nicholas Verity; Jeffrey M Axten; Catharine A Ortori; Anne E Willis; Peter M Fischer; David A Barrett; Giovanna R Mallucci
Journal:  Sci Transl Med       Date:  2013-10-09       Impact factor: 17.956
View more
  3 in total

1.  CLOCK disruption aggravates carotid artery stenosis through endoplasmic reticulum stress-induced endothelial-mesenchymal transition.

Authors:  Hanfei Tang; Song Xue; Gefei Zhao; Chao Fang; Liang Cai; Zhenyu Shi; Weiguo Fu; Ruizhe Qian; Pengfei Zhang; Xiao Tang; Daqiao Guo
Journal:  Am J Transl Res       Date:  2020-12-15       Impact factor: 4.060

2.  Clock mediates liver senescence by controlling ER stress.

Authors:  Gongsheng Yuan; Bingxuan Hua; Tingting Cai; Lirong Xu; Ermin Li; Yiqing Huang; Ning Sun; Zuoqin Yan; Chao Lu; Ruizhe Qian
Journal:  Aging (Albany NY)       Date:  2017-12-22       Impact factor: 5.682

Review 3.  Is Alzheimer's Disease a Liver Disease of the Brain?

Authors:  Margaret F Bassendine; Simon D Taylor-Robinson; Michael Fertleman; Michael Khan; Dermot Neely
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.