Literature DB >> 2813411

Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2'-deoxyguanosine.

P M Price1, R Banerjee, G Acs.   

Abstract

We report that treatment of 2.2.15, a human hepatoblastoma-derived cell line in which hepatitis B virus is actively replicating, with the carbocyclic analogue of 2'-deoxyguanosine [Shealy, Y. F., O'Dell, C. A., Shannon, W. M. & Arnett, G. (1984) J. Med. Chem. 27, 1416-1421] resulted in the nearly complete cessation of viral replication, as monitored by the absence of both intracellular episomal and secreted viral DNAs and by the absence of viral DNA polymerase activity. The drug was nontoxic in concentrations up to 200 times the minimum effective inhibitory concentration.

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Year:  1989        PMID： 2813411      PMCID： PMC298318          DOI： 10.1073/pnas.86.21.8541

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

Review 1.  Approaches to the treatment of hepatitis B virus and delta-related liver disease.

Authors:  H C Thomas; A M Lever; L J Scully; M Pignatelli
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2.  Production of hepatitis B virus by a differentiated human hepatoma cell line after transfection with cloned circular HBV DNA.

Authors:  C Sureau; J L Romet-Lemonne; J I Mullins; M Essex
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3.  In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus.

Authors:  B Lee; W X Luo; S Suzuki; M J Robins; D L Tyrrell
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191

4.  Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning.

Authors:  J H Han; C Stratowa; W J Rutter
Journal:  Biochemistry       Date:  1987-03-24       Impact factor: 3.162

5.  Maintenance of woodchuck hepatitis virus activity in woodchuck hepatocyte primary culture.

Authors:  N Thézé; P Gripon; I Fourel; O Hantz; C Trepo; C Guguen-Guillouzo
Journal:  J Gen Virol       Date:  1987-04       Impact factor: 3.891

6.  Rapid transfer of DNA from agarose gels to nylon membranes.

Authors:  K C Reed; D A Mann
Journal:  Nucleic Acids Res       Date:  1985-10-25       Impact factor: 16.971

Review 7.  Relation of the hepatitis B virus carrier state to hepatocellular carcinoma.

Authors:  H Popper; D A Shafritz; J H Hoofnagle
Journal:  Hepatology       Date:  1987 Jul-Aug       Impact factor: 17.425

8.  Stable expression and replication of hepatitis B virus genome in an integrated state in a human hepatoma cell line transfected with the cloned viral DNA.

Authors:  T Tsurimoto; A Fujiyama; K Matsubara
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

9.  Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

Authors:  M A Sells; M L Chen; G Acs
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

10.  Hepatitis B virus produced by transfected Hep G2 cells causes hepatitis in chimpanzees.

Authors:  G Acs; M A Sells; R H Purcell; P Price; R Engle; M Shapiro; H Popper
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205
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  16 in total

1.  Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus.

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Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

2.  Comparative inhibition of hepatitis B virus DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and of other nucleoside analogs.

Authors:  E Matthes; K Reimer; M von Janta-Lipinski; H Meisel; C Lehmann
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

3.  Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication.

Authors:  S K Ladner; M J Otto; C S Barker; K Zaifert; G H Wang; J T Guo; C Seeger; R W King
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

4.  Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase.

Authors:  L L Bennett; P W Allan; G Arnett; Y F Shealy; D S Shewach; W S Mason; I Fourel; W B Parker
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

5.  Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks.

Authors:  I Fourel; J M Cullen; J Saputelli; C E Aldrich; P Schaffer; D R Averett; J Pugh; W S Mason
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

6.  The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.

Authors:  P A Furman; M Davis; D C Liotta; M Paff; L W Frick; D J Nelson; R E Dornsife; J A Wurster; L J Wilson; J A Fyfe
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

7.  Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Authors:  S L Doong; C H Tsai; R F Schinazi; D C Liotta; Y C Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

8.  Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.

Authors:  S Balakrishna Pai; S H Liu; Y L Zhu; C K Chu; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

9.  Inhibition of episomal hepatitis B virus DNA in vitro by 2,4-diamino-7- (2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-pyrrolo[2,3-d]pyrimidine.

Authors:  J O Ojwang; B K Bhattacharya; H B Marshall; B E Korba; G R Revankar; R F Rando
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

10.  High-capacity in vitro assessment of anti-hepatitis B virus compound selectivity by a virion-specific polymerase chain reaction assay.

Authors:  R W Jansen; L C Johnson; D R Averett
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191
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