Literature DB >> 28129535

Cryo-EM Captures the Dynamics of Ion Channel Opening.

John L Rubinstein1.   

Abstract

In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na+-activated K+ channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID: 28129535     DOI: 10.1016/j.cell.2017.01.011

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  2 in total

Review 1.  Cryo-EM in drug discovery: achievements, limitations and prospects.

Authors:  Jean-Paul Renaud; Ashwin Chari; Claudio Ciferri; Wen-Ti Liu; Hervé-William Rémigy; Holger Stark; Christian Wiesmann
Journal:  Nat Rev Drug Discov       Date:  2018-06-08       Impact factor: 84.694

Review 2.  Developments, applications, and prospects of cryo-electron microscopy.

Authors:  Xu Benjin; Liu Ling
Journal:  Protein Sci       Date:  2019-12-26       Impact factor: 6.725

  2 in total

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