Amol Ramchandra Gadbail1, Minal Chaudhary1, Madhuri Gawande1, Alka Hande1, Sachin Sarode2, Satyajit Ashok Tekade3, Sheetal Korde4, Prajakta Zade1, Rahul Bhowate5, Rajiv Borle6, Swati Patil1. 1. Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India. 2. Department of Oral and Maxillofacial Pathology & Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India. 3. Department of Oral and Maxillofacial Pathology & Microbiology, Modern Dental College & Research Centre, Indore, Madhya Pradesh, India. 4. Department of Oral and Maxillofacial Pathology & Microbiology, Yerala Dental College and Hospital, Kharghar, Mumbai, India. 5. Department of Oral Medicine and Radiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India. 6. Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India.
Abstract
BACKGROUND: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC). METHODS: A total of 217 cases of OSCC were retrieved from achieves for the analysis. OSCC-OSMF cases were segregated on the basis of history and clinicopathological parameters. RESULTS: The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF. OSCC-OSMFs were younger compared with OSCC. Overall oral cancer was noted predominantly in males compared to females. The number of OSCC-OSMF was more in clinical TNM stage I and stage II as compared to OSCC, whereas the number of OSCC was more in stage III and stage IV compared to OSCC-OSMF. Histological presentation of well-differentiated squamous cell carcinoma was significantly more in OSCC-OSMF compared to OSCC, whereas moderately differentiated squamous cell carcinoma was significantly more in OSCC compared to OSCC-OSMF. Regional lymph node metastasis was significantly higher in OSCC compared to OSCC-OSMF. Three-year disease-free survival rate was significantly higher in OSCC-OSMF compared to OSCC. CONCLUSION: The OSCC-OSMF was found to be a clinicopathologically distinct entity with a better grade of tumor differentiation, less incidence of nodal metastases, and early detection (early clinical TNM stage) compared to OSCC. All these factors probably contribute to a better prognosis and increased 3-year disease-free survival in OSCC-OSMF patients.
BACKGROUND: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC). METHODS: A total of 217 cases of OSCC were retrieved from achieves for the analysis. OSCC-OSMF cases were segregated on the basis of history and clinicopathological parameters. RESULTS: The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF. OSCC-OSMFs were younger compared with OSCC. Overall oral cancer was noted predominantly in males compared to females. The number of OSCC-OSMF was more in clinical TNM stage I and stage II as compared to OSCC, whereas the number of OSCC was more in stage III and stage IV compared to OSCC-OSMF. Histological presentation of well-differentiated squamous cell carcinoma was significantly more in OSCC-OSMF compared to OSCC, whereas moderately differentiated squamous cell carcinoma was significantly more in OSCC compared to OSCC-OSMF. Regional lymph node metastasis was significantly higher in OSCC compared to OSCC-OSMF. Three-year disease-free survival rate was significantly higher in OSCC-OSMF compared to OSCC. CONCLUSION: The OSCC-OSMF was found to be a clinicopathologically distinct entity with a better grade of tumor differentiation, less incidence of nodal metastases, and early detection (early clinical TNM stage) compared to OSCC. All these factors probably contribute to a better prognosis and increased 3-year disease-free survival in OSCC-OSMFpatients.
Authors: Dr Shailesh M Gondivkar; Dr Amol R Gadbail; Dr Sachin C Sarode; Dr Rima S Gondivkar; Shankargouda Patil; Dr Rahul N Gaikwad; Dr Monal Yuwanati Journal: J Oral Biol Craniofac Res Date: 2020-05-18
Authors: Shailesh M Gondivkar; Amol R Gadbail; Sachin C Sarode; Rima S Gondivkar; Shankargouda Patil; Rahul N Gaikwad; Monal Yuwanati Journal: J Oral Biol Craniofac Res Date: 2020-07-03
Authors: Shailesh M Gondivkar; Amol R Gadbail; Sachin C Sarode; Subhrajit Dasgupta; Balkrishna Sharma; Amol Hedaoo; Aparna Sharma; Gargi S Sarode; Monal Yuwanati; Rima S Gondivkar; Shankargouda Patil; Rahul N Gaikwad Journal: Asian Pac J Cancer Prev Date: 2021-08-01