Literature DB >> 28126234

Characteristics, applications and prospects of mesenchymal stem cells in cell therapy.

Juan A Guadix1, José L Zugaza2, Patricia Gálvez-Martín3.   

Abstract

Recent advances in the field of cell therapy and regenerative medicine describe mesenchymal stem cells (MSCs) as potential biological products due to their ability to self-renew and differentiate. MSCs are multipotent adult cells with immunomodulatory and regenerative properties, and, given their therapeutic potential, they are being widely studied in order to evaluate their viability, safety and efficacy. In this review, we describe the main characteristics and cellular sources of MSCs, in addition to providing an overview of their properties and current clinical applications, as well offering updated information on the regulatory aspects that define them as somatic cell therapy products. Cell therapy based on MSCs is offered nowadays as a pharmacological alternative, although there are still challenges to be addressed in this regard.
Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

Keywords:  Cell therapy; Células madre mesenquimales; Medicina regenerativa; Mesenchymal stem cells; Regenerative medicine; Terapia celular

Mesh:

Year:  2017        PMID: 28126234     DOI: 10.1016/j.medcli.2016.11.033

Source DB:  PubMed          Journal:  Med Clin (Barc)        ISSN: 0025-7753            Impact factor:   1.725


  20 in total

Review 1.  Therapeutic Application of Mesenchymal Stem Cells for Cochlear Regeneration.

Authors:  Nagarajan Maharajan; Gwang Won Cho; Chul Ho Jang
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

2.  Effects of mesenchymal stromal cells on motor function and collagen in the skeletal muscles of rats with type I diabetes.

Authors:  Genoveva L F Luna; Thiago L Russo; Maria A Sabadine; Yisel C Estrada-Bonilla; Ana L M Andrade; Patricia Brassolatti; Fernanda F Anibal; Ângela M O Leal
Journal:  Int J Exp Pathol       Date:  2020-02-06       Impact factor: 1.925

3.  Optimisation of a potency assay for the assessment of immunomodulative potential of clinical grade multipotent mesenchymal stromal cells.

Authors:  Irene Oliver-Vila; Carmen Ramírez-Moncayo; Marta Grau-Vorster; Sílvia Marín-Gallén; Marta Caminal; Joaquim Vives
Journal:  Cytotechnology       Date:  2018-01-10       Impact factor: 2.058

Review 4.  Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates.

Authors:  Paul Palmquist-Gomes; José María Pérez-Pomares; Juan Antonio Guadix
Journal:  Heart Fail Rev       Date:  2019-01       Impact factor: 4.214

5.  Cutaneous wound healing: canine allogeneic ASC therapy.

Authors:  Nathaly Enciso; Luis Avedillo; María Luisa Fermín; Cristina Fragío; Concepción Tejero
Journal:  Stem Cell Res Ther       Date:  2020-06-29       Impact factor: 6.832

6.  The directional migration and differentiation of mesenchymal stem cells toward vascular endothelial cells stimulated by biphasic calcium phosphate ceramic.

Authors:  Ying Chen; Jing Wang; Xiangdong Zhu; Xuening Chen; Xiao Yang; Kai Zhang; Yujiang Fan; Xingdong Zhang
Journal:  Regen Biomater       Date:  2017-10-31

7.  HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study.

Authors:  Marta Grau-Vorster; Anita Laitinen; Johanna Nystedt; Joaquim Vives
Journal:  Stem Cell Res Ther       Date:  2019-06-13       Impact factor: 6.832

8.  Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton's Jelly.

Authors:  Marta Grau-Vorster; Luciano Rodríguez; Anna Del Mazo-Barbara; Clémentine Mirabel; Margarita Blanco; Margarita Codinach; Susana G Gómez; Sergi Querol; Joan García-López; Joaquim Vives
Journal:  Cells       Date:  2019-05-21       Impact factor: 6.600

Review 9.  Mesenchymal stem cells for cardiac repair: are the actors ready for the clinical scenario?

Authors:  Santiago Roura; Carolina Gálvez-Montón; Clémentine Mirabel; Joaquim Vives; Antoni Bayes-Genis
Journal:  Stem Cell Res Ther       Date:  2017-10-27       Impact factor: 6.832

10.  Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model.

Authors:  Babak Arjmand; Parisa Goodarzi; Hamid Reza Aghayan; Moloud Payab; Fakher Rahim; Sepideh Alavi-Moghadam; Fereshteh Mohamadi-Jahani; Bagher Larijani
Journal:  Front Endocrinol (Lausanne)       Date:  2019-11-06       Impact factor: 5.555

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