H Gur1, Y Alimoglu2, U Duzenli1, S Korkmaz1, S Inan3, L Olgun1. 1. Otolaryngology Department,Bozyaka Training and Research Hospital,Izmir,Turkey. 2. Otolaryngology Department,Haseki Training and Research Hospital,Istanbul,Turkey. 3. Histology Department,Medical Faculty,Celal Bayar University,Manisa,Turkey.
Abstract
BACKGROUND: Electrode insertion during cochlear implantation causes cochlear damage and apoptosis. Insulin-like growth factor applied locally was investigated in 21 rats. METHODS: In the sham group, an intracochlear dummy electrode was inserted through the round window. In the control group, after the same insertion procedure, saline-soaked porcine skin gelatine was placed on the round window. In the study group, insulin-like growth factor 1 soaked gelatine was placed on the round window. Auditory brainstem response thresholds were measured and histopathological examination was performed. RESULTS: In the study group, at 2-4 kHz, one rat had deterioration, one showed improvement and the rest had stable thresholds 14 days after intervention. At 6 kHz, four rats showed improvement and the rest remained stable. At 8 kHz, four showed improvement, one had deterioration and two remained stable. In the other groups, hearing loss deteriorated in about half of the rats and remained stable in the rest. The mean post-operative 6 kHz threshold was significantly lower than that immediately after the intervention in the study group, contrary to the other groups. The study group had significantly better mean histopathological grading than the other groups. CONCLUSION: Local insulin-like growth factor 1 application may protect hearing after cochlear implantation.
BACKGROUND: Electrode insertion during cochlear implantation causes cochlear damage and apoptosis. Insulin-like growth factor applied locally was investigated in 21 rats. METHODS: In the sham group, an intracochlear dummy electrode was inserted through the round window. In the control group, after the same insertion procedure, saline-soaked porcine skin gelatine was placed on the round window. In the study group, insulin-like growth factor 1 soaked gelatine was placed on the round window. Auditory brainstem response thresholds were measured and histopathological examination was performed. RESULTS: In the study group, at 2-4 kHz, one rat had deterioration, one showed improvement and the rest had stable thresholds 14 days after intervention. At 6 kHz, four rats showed improvement and the rest remained stable. At 8 kHz, four showed improvement, one had deterioration and two remained stable. In the other groups, hearing loss deteriorated in about half of the rats and remained stable in the rest. The mean post-operative 6 kHz threshold was significantly lower than that immediately after the intervention in the study group, contrary to the other groups. The study group had significantly better mean histopathological grading than the other groups. CONCLUSION: Local insulin-like growth factor 1 application may protect hearing after cochlear implantation.
Authors: Cristina Maria Blebea; Laszlo Peter Ujvary; Violeta Necula; Maximilian George Dindelegan; Maria Perde-Schrepler; Mirela Cristina Stamate; Marcel Cosgarea; Alma Aurelia Maniu Journal: Medicina (Kaunas) Date: 2022-05-31 Impact factor: 2.948
Authors: Cristina Maria Blebea; Violeta Necula; Monica Potara; Maximilian George Dindelegan; Laszlo Peter Ujvary; Emil Claudiu Botan; Alma Aurelia Maniu; Marcel Cosgarea Journal: Audiol Res Date: 2022-08-28