Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.

The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non-invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4-1 and PTEN was determined by immunohistochemistry. NEDD4-1 was revealed to be located in the nucleus and cytoplasm, whereas PTEN was only located in the cytoplasm. Furthermore, expression of NEDD4-1 was higher in pituitary adenomas compared with normal pituitary tissues (P<0.05), and higher in the invasive group compared with the non-invasive group, whereas the opposite trend was observed for PTEN. There was a strong negative correlation between NEDD4-1 and PTEN expression, indicating a dependency between the two and an association with invasiveness. In conclusion, NEDD4-1 may serve as a diagnostic and prognostic factor, and as a novel therapeutic target, in pituitary adenomas.