Tim Westland1,2, Eliza K Patryn3, Carla P Nieuwendaal4, Ivanka J E van der Meulen4, Maarten P Mourits3,4, Ruth Lapid-Gortzak4,5. 1. Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands. westland.tim@gmail.com. 2. Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. westland.tim@gmail.com. 3. Department of Ophthalmology, Oogziekenhuis Zonnestraal, Amsterdam, The Netherlands. 4. Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. 5. Retina Total Eye Care, Driebergen, The Netherlands.
Abstract
PURPOSE: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. METHODS: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. RESULTS: Quick resolution of the shield ulcers and complete re-epithelialization within 14-25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. CONCLUSIONS: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.
PURPOSE: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. METHODS: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. RESULTS: Quick resolution of the shield ulcers and complete re-epithelialization within 14-25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. CONCLUSIONS: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.
Authors: S Bonini; S Bonini; A Lambiase; S Marchi; P Pasqualetti; O Zuccaro; P Rama; L Magrini; T Juhas; M G Bucci Journal: Ophthalmology Date: 2000-06 Impact factor: 12.079
Authors: Ruchi Shah; Cynthia Amador; Kati Tormanen; Sean Ghiam; Mehrnoosh Saghizadeh; Vaithi Arumugaswami; Ashok Kumar; Andrei A Kramerov; Alexander V Ljubimov Journal: Exp Eye Res Date: 2021-01-21 Impact factor: 3.467