Monitoring Step Activity During Task-Oriented Circuit Training in High-Functioning Chronic Stroke Survivors: A Proof-of-Concept Feasibility Study.

OBJECTIVE: To explore the amount of practice and progression during task-oriented circuit training (TOCT) in chronic stroke survivors; to test the use of pedometers and observation-based measures in detecting step activity; to verify the possible correlation between step activity and locomotor function improvements.
METHODS: Six community-dwelling chronic stroke survivors underwent 10 TOCT sessions (2 hours/each) over 2 weeks in which they were trained both on a treadmill and on six task-oriented workstations (W1-W6). During the sessions, they wore a piezoelectric pedometer and step activities were recorded. Outcome measures were as follows: % of activities during which pedometers worked properly; pedometer-based measures (total step counts, treadmill steps, workstation steps-total and W2,W3,W5,W6); observation-based measures (number of repetitions in task W1 and W4); walking speed changes measured by the 10-m walking test (10MWT) and walking endurance changes (6-minute walking test) after TOCT.
RESULTS: During TOCT sessions (n=57), activities were recorded through pedometer-based measures in 4 out of the 6 patients. The total amount of step activity was 5,980.05±1,968.39 steps (54.29% in task-oriented workstations, 37.67% on treadmill, and 8.03% during breaks). Exercise progression was highlighted significantly by observational measures (W1, W4). A positive correlation was observed between increased gait speed and observational stair step repetitions progression (W1) (r=0.91, p=0.01) or pedometer-based tandem exercise step progression (W3) (r=0.98, p=0.01).
CONCLUSION: TOCT can be considered a high-intensity, progressive intervention to restore locomotor function in chronic stroke survivors. Pedometer-based measures might help in quantifying TOCT's volume of practice; however, further investigations are required.

INTRODUCTION

Stroke is a leading cause of motor impairments and disability worldwide, and even in the chronic phase, survivors tend to be inactive which produces detrimental effects on mobility and quality of life [1]. Repetition, intensity and specificity of motor tasks are the essential key factors of learning-dependent neural plasticity and the amount of practice might influence functional recovery after stroke [2]. In clinical practice, it is now widely accepted that high-intensity and task-specific interventions, such as task-oriented circuit training (TOCT), are pivotal to achieve functional recovery after stroke [34]. TOCT is a relatively new concept in neurorehabilitation and it consists of progressive task-specific therapy provided in a group setting (class) [5]. TOCT is based on progressive task-specific exercises through workstations, in which subjects can be trained intensively on functional motor tasks. The duration of tasks, the frequency and progression have to be tailored according to the subjects’ characteristics. Motor tasks should always be challenging and motivating to ensure neuroplastic changes and skills consolidation [26]; variety in practice and motor task salience are also essential. Participation of other patients in the same session might increase motivation, promote good competition and improve self-esteem; therefore, therapy adherence can be higher compared to that for an individual physiotherapy session. Another potential benefit of groups is that action observation might enhance motor learning and skills acquisition; indeed, when an action is observed, the brain generates activity that is similar to what occurs when the action is performed [7]. Finally, this new organization method has the potential to deliver more active therapy compared to the conventional one-to-one approach and to reduce staff costs [5].

It is well-known how a positive relationship develops between exercise intensity and outcomes [8]. Therefore, quantifying the volume of practice is an important topic in stroke rehabilitation research, and in a clinical trial, it is recommended to report repetitions of an exercise for a more accurate representation of the dose of the therapy received [8]. However, the definition of “dose” of practice is still an unsolved issue; so far, intensity has been described as “frequency of repetition of a specific movement” [91011], or “amount of external work” [12] or “amount of time dedicated to practice” [13]. Measuring the external work or power is not feasible during TOCT; for this reason, we decided to focus our attention on the frequency of step repetitions, as it is directly related to the actual amount of practice. Previous studies on stroke survivors measured the duration of motor activity by video-taping or based on the therapist’s report [914]; whereas few studies quantified the amount of practice during stroke rehabilitation [4101516]. Pedometers are wearable devices that provide useful information on physical activity [17] and they can also be used in stroke survivors [18] to detect daily step activity [1] or to assist in the community-based walking program [19]. The specific aims of this study were (1) to explore the volume of practice and progression during 120 minutes of TOCT and to assess their possible correlation with locomotor function improvements; (2) to test the use of pedometer- and observation-based measures in detecting step activity during TOCT.

MATERIALS AND METHODS

In a convenience sample, part of a pilot study where we assessed the effects of TOCT and transcranial direct current stimulation in patients with chronic stroke (NCT01883843), we quantified the amount of practice and exercise progression. Subjects were aged 18–75 years, with a diagnosis of first ischemic/hemorrhagic stroke >6 months, community-dwelling with a Functional Ambulation Classification (FAC) score ≥4 that refers to patients who can walk independently on level ground but require help on stairs, slopes or uneven surfaces. Exclusion criteria were: (1) contraindications for tDCS; (2) medical conditions likely to interfere with the ability to complete the study safely; (3) impaired cognitive functioning (Mini Mental Status Examination score <24). All subjects underwent TOCT (10 sessions over 2 weeks); each session (2 hours) was divided between the treadmill (up to 30 minutes) and six task-oriented workstations (W1–W6) in which subjects exercised for 5 minutes on each equipment (3 minutes of exercises and 2 minutes of rest). Workstations have been described in Table 1. During each session, subjects underwent 2 laps that took about 60 minutes (6 workstations×5 minutes×2 laps), with 10 minutes of rest after each lap. This was a progressive circuit and subjects while exercising received feedbacks (visual and auditory) from the physiotherapist. Rests were used to discuss regarding difficulties and to provide further feedbacks. One session included up to 3 patients [20].

Table 1

Methods of assessing step activity and repetitions during task-oriented circuit training

Patients signed a written informed consent form approved by the Ethical Committee. During activities, patients wore a piezoelectric pedometer (Geonaute ONStep 100), which has been shown to be more suitable for subjects with low speed (i.e., stroke survivors) [17]. It was set according to the patients’ anthropomorphic characteristics (height, weight) and was attached to the unaffected hip [18] at the beginning of each session and taken off at the end of training. We recorded step activity during each TOCT session (rest and breaks included); furthermore, workstation and treadmill step activities were manually recorded in a precompiled log; in two workstations, stair step (W1) and goal (W4), we hypothesized that the use of the pedometer was not appropriate to detect repetition; therefore, the number of task repetitions observed was reported (observation-based measures). Data were collected by two physiotherapists (CM and AB).

The 10-m walking test (10MWT) and the 6-minute walking test (6MWT) were performed pre- and post-training to detect any changes in locomotor function. Moreover, walking speed was used to classify the sample into the walking behaviour (household ambulators, <0.4 m/s; limited community ambulators, 0.4–0.8 m/s; and community ambulators, >0.8 m/s) [21]. Also, the use of walking aids or the presence of major kinematic deviations was reported. The two physiotherapists assessed the subjects’ gait by observing their walk and categorizing it as ‘normal’ or ‘hemiparetic.’ If they failed to agree, they discussed it until an agreement was reached.

Statistical analysis

Descriptive statistics as means and standard deviations were used to analyse workstation and treadmill step activity. We calculated the percentages of activities performed during the sessions and also the percentages of activities where it was possible to record steps with pedometers to test the feasibility of pedometer-based measures. We registered the total steps (break and rests included), total steps during each workstation activity and total steps on the treadmill to test the ability of measures to determine exercise volume for each session. We analysed the differences among sessions using the ANOVA repeated measures analysis, and Tukey’s post-hoc pairwise comparison to underline exercise progression. Moreover, the effect size (Cohen’s d) was calculated for each variable considering the progression between sessions 1 and 10. Pearson coefficient correlation was used to test any possible association between exercise progression and clinical gains. All data available were included in the final analysis; missing data were handled with the last observation carried forward approach, and conditions when the pedometers did not record properly were excluded. Significance levels were set at p<0.05. STATA/IC ver. 13 was used for statistical analysis.

RESULTS

We tested the use of pedometers in six community-dwelling chronic stroke survivors (3 men, 3 women; mean age, 58.67±14.18 years, 6.2±6.1 years after stroke). Sample characteristics are summarized in Table 2.

Table 2

Characteristics of study subjects (n=6)

Values are presented as mean±standard deviation or number.

FAC, Functional Ambulation Classification; ND, not defined.

We analyzed data recorded over 57 TOCT sessions performed by six community-dwelling chronic stroke survivors over 2 weeks (3 subjects missed 1 session for personal issues). According to their speed-based walking performance, 2 subjects (33%) were classified as limited community ambulators (<0.8 m/s), whereas 4 subjects (66%) were classified as full community ambulators (gait speed >0.8 m/s) [21]. None of the subjects needed walking aids (0%) and three out of the 6 subjects had major hemiparetic gait abnormalities (50%). No injuries, falls or fatigability were recorded throughout the sessions. Pedometers were easily worn under the PT’s supervision and they did not interfere with activities or were not displaced during exercises.

During the TOCT sessions, 94.1%±5.9% of the pre-determined motor activities were performed by our sample and the subjects walked on a treadmill for 24.37±7.91 minutes (min 4–max 30) at 0.9–1.8 mph. Pedometer-based measures were obtained in 66.5%±51.4% of these activities. Specifically, in 4 out of the 6 subjects, we recorded >98% of all episodes, whereas in 2 subjects, the pedometer failed to work properly. They were characterized by lower gait speed (0.79 m/s and 0.71 m/s) and major hemiparetic gait abnormalities. Considering how these variables might reflect malfunctioning of the pedometers [18], we correlated these data with baseline gait speed (r=0.88, p<0.01) and gait abnormalities (r=0.70, p=0.11).

The total amount of step activity during each 120-minute session was 5,980.05±1,968.39 steps (breaks and rests included), with an overall mean cadence of 49 steps/min; this was distributed as follows: 54.29% in 60 minutes of task-oriented workstations (54 steps/min), 37.67% during the treadmill exercise (93 steps/min), and 8.03% during breaks (30 minutes). Regarding progression across sessions, the patients were able to increase the number of repetitions significantly for the stair step (F=4.35, p<0.001) and goals in workstation (F=3.67, p<0.01). However, a medium to large effect size (Cohen’s d) between the first and last session in each workstation was reported, as shown in Table 3. A power analysis was conducted, and considering the lower effect size (d=0.56) registered in slalom workstation (W2), 90% power and alpha of 5%, it will be necessary to enroll 29 subjects in a future study to detect any significant progression in each workstation.

Table 3

Step activity: exercise intensity and progression

Values are presented as mean±standard deviation.

W1, step; W2, slalom; W3, tandem exercise; W4, goals; W5, obstacles; W6, long step; ES, effect size (calculated for each variable considering the progression between sessions 1 and 10); rep, repetition; WS, workstations.

*p<0.05, Tukey's pairwise comparisons test (referred to session 1).

Pre-training walking speed was 1.02±0.23 m/s, which increased to 1.14±0.24 m/s after treatment (p<0.05), whereas walking endurance was 247.23±20.68 m and it increased to 291.1±24.58 m. We found a positive correlation between increased gait speed and observation-based stair step repetitions progression (W1) (r=0.91, p=0.01) or pedometer-based tandem exercise step progression (W3) (r=0.98, p=0.01), as reported in Fig. 1.

Fig. 1

Correlation between clinical outcome (gait speed) and exercise progression (S1–S10). (A) observation-based stair step repetitions workstation (W1) (r=0.91, p=0.01). (B) Pedometer-based tandem workstation (W3) (r=0.98, p=0.01).

Moreover, correlations close to achieving significance were found with total step counts progression (r=0.88, p=0.11), pedometer-based obstacles step progression (r=0.81, p=0.18) and total workstation step progression (r=0.83, p=0.06). We found a correlation close to achieving significance between walking endurance and total step counts progression (r=0.85, p=0.14).

DISCUSSION

In this proof-of-concept feasibility study, we explored the use of pedometer-based and observational-based measures to count step activity and progression during TOCT sessions in community-dwelling chronic stroke survivors. Evidence from animal models showed how induction of neuroplasticity requires sufficient training intensity. In addition to repetition, intensity of training can also affect induction of cortical reorganization processes. Indeed, it has been shown how animals trained on a skilled reaching task to perform 400 reaches per day had an increase in synapse number within motor cortex [22], whereas animals trained to reach 60 times per day did not have such increases [23]. In clinical practice, it is well-known how a positive relationship develops between intensity and outcome. Furthermore, it is recommended to report repetitions of an exercise for a more accurate representation of the dose of the therapy received [8]. In rehabilitation medicine, the definition of “dose” of practice remains one of the unsolved issues. In this paper, we considered intensity as “frequency of repetition of a task” [491011]. However, from the exercise physiology viewpoint, the term “intensity” refers to the amount of external work produced during a motor task. Unfortunately, measuring the energy spent to perform certain motor tasks is not always feasible due to the lack of equipment required to measure the external power produced. For this reason, in rehabilitation medicine, the number of repetitions of a motor task [491011] or the time spent on practice [24] is commonly used to reflect the dose of practice applied, even if it is considered to be a less optimal estimate.

In our sample, the pedometer was feasible only in subjects who were classified as full community ambulators (gait speed >0.8 m/s). Previous studies reported about low accuracy of pedometers in detecting steps in subjects with low speed [1718], although this did not seem to be the only factor (i.e., the use of walking aids and the presence of kinematic gait deviations) [18]. Our findings suggested that pedometers were suitable in subjects with gait speed >0.8 m/s, as previously reported by Fulk et al. [25], who tested the accuracy of activity monitors and pedometers in a sample of community ambulators with chronic stroke who walked at 0.83 m/s. Below this threshold our pedometers did not record step counts, which are higher than those detected by Carroll et al. [18] (about 0.5 m/s); we can hypothesize that this discrepancy is because of the concomitant presence of kinematic gait deviations in our subjects.

During a TOCT session, our sample maintained an overall cadence of 49 steps/min, which reflects a ‘high intensity’ intervention for stroke survivors that can contribute to cardiovascular health [1]. This intervention combines both locomotor activity on a treadmill and in different contexts where subjects performed numerous repetitions of a single task (long steps, slaloms, tandem, passing small obstacles, stair steps and achieving goals) that seems to be essential for neuroplasticity and motor recovery [26]. Clearly, these activities require slower speeds and increased attention compared to walking on a treadmill, which explains the different aerobic intensities (54 steps/min vs. 93 steps/min).

Considering how repetitions, progression and specificity are the key factors in motor learning and rehabilitation gains [2], we counted the number of repetitions during the step (W1) and achieving goals (W4) task; otherwise, we considered pedometer step counts over the entire session, divided them into treadmill and workstation activities. The amount of stair steps achieved during TOCT was 3- to 6-fold higher compared to that in other studies [410] which assessed the amount of stair task repetitions during conventional stroke physiotherapy sessions [10] or a task-oriented session in acute stroke survivors [4]. Considering the whole step activity during TOCT (2 hours), subjects performed approximately 1,500 steps more than those during 1 hour of intensive locomotor training, which is still 4-fold more intensive than 1 hour of conventional physiotherapy [15]. In conclusion, 2 hours of TOCT provides approximately 4,500 steps more than those during 1 hour of conventional physiotherapy [1015]; the volume of practice was similar to that reported by Holleran et al. [16] who, in chronic stroke survivors, delivered 2,967 steps during 1 hour of stepping activities (treadmill, overground and stair climbing), even though their target population had a significantly lower locomotor function (0.56 m/s vs. 1.02 m/s). Observation-based measures rather than pedometer-based measures were accurate enough to detect progression among sessions; nevertheless, even pedometer-based measures, collected during workstation and treadmill activities, revealed a medium to large effect size (0.56–0.85). As reported previously, pedometers are a valid device to measure step activity in ambulatory stroke survivors; however, they tend to undercount steps during other activities of short duration [27]. Furthermore, other activity monitor devices may be more accurate than pedometers to detect walking activities in chronic stroke survivors [25].

After TOCT, we found an overall improvement in walking speed, 0.12 m/s which is above the minimally clinical important difference (MCID) stated for the 10MWT [28]. This finding reflects the positive effects of a task-oriented intervention in community ambulators who are chronic stroke survivors. Furthermore, when we looked at a possible dose-response relationship among the variable selected (step activities) and locomotor function improvements, we found a positive correlation between stair-step progression, measured by observation, tandem progression, measured by the pedometer and speed gains. This corroborates the hypothesis that a higher volume of training (i.e., stair step repetitions) may enhance gait speed in chronic stroke survivors [24]. In future larger studies, it would be worthwhile to test if a low-cost pedometer, as used in this proof-of-concept study, is accurate enough to detect significant changes in step activity progression with a solid correlation with functional outcome. This might provide a great contribution to the field of the dose-response relationship in stroke rehabilitation medicine research. Moreover, future studies should aim at determining which components (treadmill, different workstations) lead to this functional gain.

This proof-of-concept study has several limitations. Firstly, the small number of observations and the low variability in gait speed between subjects reduce the generalization of the results. Indeed, our sample is quite high-functioning, with a pre-training walking speed of 1.02 m/s, which is quite high compared to that in many patients seen in a rehabilitation setting who usually ambulate at a much slower pace. In future studies, it would be worth considering patients with slower speeds, even if in this preliminary report, our pedometers failed to record step activity in 2 subjects with gait speed <0.8 m/s. Secondly, the accuracy of the pedometer device used in this paper has not been tested previously (i.e., compared to observation or accelerometer), even if similar devices have been tested [2527]. Thirdly, the mere observation of kinematic gait deviations (yes/no) might not represent the most effective way to detect gait abnormalities; in future researches, the additional use of instrumental gait analysis might help determine the patients who are better suited to use pedometers during a rehabilitative intervention.

In conclusion, TOCT can be considered a high-intensity, progressive intervention to restore locomotor function in chronic stroke survivors. Our report suggested a novel use of pedometers, not only for monitoring step activity in real-life conditions but also during rehabilitation, in high-functioning stroke survivors. In our report, exercise dose was tightly controlled and this model can be replicated in future clinical trials including a new metric of intensity, in addition to duration of therapy.