Benedetta Piccardi1, Dolors Giralt2, Alejandro Bustamante2, Victor Llombart2, Teresa García-Berrocoso2, Domenico Inzitari1,3, Joan Montaner2. 1. a Neuroscience Section, Department of Neurofarba , University of Florence , Florence , Italy. 2. b Neurovascular Research Laboratory , Vall d'Hebron University Hospital Research Institute (VHIR), Universitat Autònoma de Barcelona , Barcelona , Spain. 3. c Institute of Neuroscience, Italian National Research Council , Florence , Italy.
Abstract
CONTEXT: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. OBJECTIVE: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes. METHODS: We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles. RESULTS: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001) Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.
CONTEXT: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes. OBJECTIVE: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes. METHODS: We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles. RESULTS: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001) Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.
Authors: Waleed Brinjikji; Sharon Duffy; Anthony Burrows; Werner Hacke; David Liebeskind; Charles B L M Majoie; Diederik W J Dippel; Adnan H Siddiqui; Pooja Khatri; Blaise Baxter; Raul Nogeuira; Matt Gounis; Tudor Jovin; David F Kallmes Journal: J Neurointerv Surg Date: 2016-05-10 Impact factor: 5.836
Authors: Eva Skiöldebrand; Annika Lundqvist; Ulrika Björklund; Mikael Sandstedt; Anders Lindahl; Elisabeth Hansson; Lillemor Mattsson Hultén Journal: Heliyon Date: 2017-10-03