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Literature DB >> 28117446

Cell biology: Unconventional translation in cancer.

Marianne Terndrup Pedersen¹, Kim B Jensen¹.

Abstract

Entities: Disease

Mesh：

Year: 2017 PMID： 28117446 DOI： 10.1038/nature21115

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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11 in total

1. Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.

Authors: Shelley R Starck; Vivian Jiang; Mariana Pavon-Eternod; Sharanya Prasad; Brian McCarthy; Tao Pan; Nilabh Shastri
Journal: Science Date: 2012-06-29 Impact factor: 47.728

2. Translation from unconventional 5' start sites drives tumour initiation.

Authors: Ataman Sendoel; Joshua G Dunn; Edwin H Rodriguez; Shruti Naik; Nicholas C Gomez; Brian Hurwitz; John Levorse; Brian D Dill; Daniel Schramek; Henrik Molina; Jonathan S Weissman; Elaine Fuchs
Journal: Nature Date: 2017-01-11 Impact factor: 49.962

3. PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism.

Authors: Hui Liang; Shiming He; Jingyi Yang; Xinying Jia; Pan Wang; Xi Chen; Zhong Zhang; Xiajuan Zou; Michael A McNutt; Wen Hong Shen; Yuxin Yin
Journal: Cell Metab Date: 2014-04-24 Impact factor: 27.287

Cell biology: Unconventional translation in cancer.

1. Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.

2. Translation from unconventional 5' start sites drives tumour initiation.

3. PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism.

Review 4. Targeting the translation machinery in cancer.

Review 5. Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment.

6. The eIF2A knockout mouse.

7. Translation from the 5' untranslated region shapes the integrated stress response.

Review 8. Ribosome profiling reveals the what, when, where and how of protein synthesis.

9. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.

Review 10. Gene expression regulation by upstream open reading frames and human disease.

Review 1. Translation acrobatics: how cancer cells exploit alternate modes of translational initiation.