Literature DB >> 28116957

Prevention and treatment of diabetic foot ulcers.

Jonathan Zhang Ming Lim1, Natasha Su Lynn Ng2, Cecil Thomas1.   

Abstract

The rising prevalence of diabetes estimated at 3.6 million people in the UK represents a major public health and socioeconomic burden to our National Health Service. Diabetes and its associated complications are of a growing concern. Diabetes-related foot complications have been identified as the single most common cause of morbidity among diabetic patients. The complicating factor of underlying peripheral vascular disease renders the majority of diabetic foot ulcers asymptomatic until latter evidence of non-healing ulcers become evident. Therefore, preventative strategies including annual diabetic foot screening and diabetic foot care interventions facilitated through a multidisciplinary team have been implemented to enable early identification of diabetic patients at high risk of diabetic foot complications. The National Diabetes Foot Care Audit reported significant variability and deficiencies of care throughout England and Wales, with emphasis on change in the structure of healthcare provision and commissioning, improvement of patient education and availability of healthcare access, and emphasis on preventative strategies to reduce morbidities and mortality of this debilitating disease. This review article aims to summarise major risk factors contributing to the development of diabetic foot ulcers. It also considers the key evidence-based strategies towards preventing diabetic foot ulcer. We discuss tools used in risk stratification and classifications of foot ulcer.

Entities:  

Keywords:  diabetic foot ulcer; growth factor; offloading; wound debridement; wound dressing

Mesh:

Year:  2017        PMID: 28116957      PMCID: PMC5349377          DOI: 10.1177/0141076816688346

Source DB:  PubMed          Journal:  J R Soc Med        ISSN: 0141-0768            Impact factor:   5.344


  28 in total

1.  Maggot debridement therapy for the treatment of diabetic foot ulcers: a meta-analysis.

Authors:  X Tian; X M Liang; G M Song; Y Zhao; X L Yang
Journal:  J Wound Care       Date:  2013-09       Impact factor: 2.072

Review 2.  The pathogenesis of diabetic foot problems: an overview.

Authors:  A J Boulton
Journal:  Diabet Med       Date:  1996       Impact factor: 4.359

Review 3.  Glucose control and diabetic neuropathy: lessons from recent large clinical trials.

Authors:  Lynn Ang; Mamta Jaiswal; Catherine Martin; Rodica Pop-Busui
Journal:  Curr Diab Rep       Date:  2014       Impact factor: 4.810

Review 4.  Enhanced glucose control for preventing and treating diabetic neuropathy.

Authors:  Brian C Callaghan; Ann A Little; Eva L Feldman; Richard A C Hughes
Journal:  Cochrane Database Syst Rev       Date:  2012-06-13

Review 5.  Preventing foot ulcers in patients with diabetes.

Authors:  Nalini Singh; David G Armstrong; Benjamin A Lipsky
Journal:  JAMA       Date:  2005-01-12       Impact factor: 56.272

6.  Negative pressure wound therapy: an evidence-based analysis.

Authors: 
Journal:  Ont Health Technol Assess Ser       Date:  2006-07-01

7.  Wound dressings in diabetic foot disease.

Authors:  J R Hilton; D T Williams; B Beuker; D R Miller; K G Harding
Journal:  Clin Infect Dis       Date:  2004-08-01       Impact factor: 9.079

8.  Reduction in diabetic amputations over 11 years in a defined U.K. population: benefits of multidisciplinary team work and continuous prospective audit.

Authors:  Singhan Krishnan; Fiona Nash; Neil Baker; Duncan Fowler; Gerry Rayman
Journal:  Diabetes Care       Date:  2007-10-12       Impact factor: 19.112

Review 9.  Mechanisms and management of diabetic painful distal symmetrical polyneuropathy.

Authors:  Solomon Tesfaye; Andrew J M Boulton; Anthony H Dickenson
Journal:  Diabetes Care       Date:  2013-09       Impact factor: 19.112

10.  Impact of glycemic control strategies on the progression of diabetic peripheral neuropathy in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Cohort.

Authors:  Rodica Pop-Busui; Jiang Lu; Maria Mori Brooks; Stewart Albert; Andrew D Althouse; Jorge Escobedo; Jenifer Green; Pasquale Palumbo; Bruce A Perkins; Fred Whitehouse; Teresa L Z Jones
Journal:  Diabetes Care       Date:  2013-06-11       Impact factor: 19.112

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  37 in total

1.  Low-concentration DMSO accelerates skin wound healing by Akt/mTOR-mediated cell proliferation and migration in diabetic mice.

Authors:  Wei Guo; Wei Qiu; Xiang Ao; Weiqiang Li; Xiao He; Luoquan Ao; Xueting Hu; Zhan Li; Ming Zhu; Donglin Luo; Wei Xing; Xiang Xu
Journal:  Br J Pharmacol       Date:  2020-04-07       Impact factor: 8.739

2.  Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials.

Authors:  Kannan Sridharan; Gowri Sivaramakrishnan
Journal:  Br J Clin Pharmacol       Date:  2018-01-05       Impact factor: 4.335

Review 3.  Immune aging in diabetes and its implications in wound healing.

Authors:  J Moura; P Madureira; E C Leal; A C Fonseca; E Carvalho
Journal:  Clin Immunol       Date:  2019-02-05       Impact factor: 3.969

Review 4.  Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes.

Authors:  Caitlin W Hicks; Elizabeth Selvin
Journal:  Curr Diab Rep       Date:  2019-08-27       Impact factor: 4.810

5.  Effectiveness of Injected Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer Disease.

Authors:  Asad Ullah; Syed I Jawaid; Pir Naveed Ahmed Ahsan Qureshi; Tehreem Siddiqui; Khadija Nasim; Kantash Kumar; Shafqat Ullah; Mustafa Sajjad Cheema; Nikita Kumari; Hafiza Azad Elias
Journal:  Cureus       Date:  2022-08-23

Review 6.  Do patients with diabetic foot ulcer need booster dose of tetanus vaccine?

Authors:  Zahra Hoseini Tavassol; Zahra Sajjadpour; Shirin Hasani-Ranjbar; Mahnaz Pejman Sani; Hamidreza Aghaei Meybodi; Bagher Larijani
Journal:  J Diabetes Metab Disord       Date:  2022-01-30

7.  Development of Apremilast Nanoemulsion-Loaded Chitosan Gels: In Vitro Evaluations and Anti-Inflammatory and Wound Healing Studies on a Rat Model.

Authors:  Mohammed Muqtader Ahmed; Md Khalid Anwer; Farhat Fatima; Amer S Alali; Mohd Abul Kalam; Ameeduzzafar Zafar; Sultan Alshehri; Mohammed M Ghoneim
Journal:  Gels       Date:  2022-04-20

8.  Ozone therapy as an alternative method for the treatment of diabetic foot ulcer: a case report.

Authors:  Navid Faraji; Rasoul Goli; Babak Choobianzali; Soheyla Bahrami; Ali Sadeghian; Nazila Sepehrnia; Mahmoodreza Ghalandari
Journal:  J Med Case Rep       Date:  2021-05-13

Review 9.  The effects of dietary/herbal supplements and the serum levels of micronutrients on the healing of diabetic foot ulcers in animal and human models: a systematic review.

Authors:  Mohammad Reza Amini; Maryam Aalaa; Ensieh Nasli-Esfahani; Rasha Atlasi; Mahnaz Sanjari; Nazli Namazi
Journal:  J Diabetes Metab Disord       Date:  2021-05-26

10.  Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement to Promote Soft Tissue Granulation in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized Controlled Trial.

Authors:  Regis Ernest Mendame Ehya; Hao Zhang; Baiwen Qi; Aixi Yu
Journal:  J Diabetes Res       Date:  2021-07-13       Impact factor: 4.011

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