Literature DB >> 28111677

Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease.

Chung Ying Chan1, Asif Noor2, Catriona A McLean3, Paul S Donnelly2, Peter J Barnard1.   

Abstract

A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyloid plaques in human frontal cortex brain tissue from subjects with Alzheimer's disease.

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Year:  2017        PMID： 28111677     DOI： 10.1039/c6cc10066j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.

Authors:  Kaihua Chen; Mengchao Cui
Journal:  Medchemcomm       Date:  2017-05-16       Impact factor: 3.597

2.  Rhenium and technetium complexes of thioamide derivatives of pyridylhydrazine that bind to amyloid-β plaques.

Authors:  Scott P Fletcher; Asif Noor; James L Hickey; Catriona A McLean; Jonathan M White; Paul S Donnelly
Journal:  J Biol Inorg Chem       Date:  2018-07-07       Impact factor: 3.358

3.  A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation.

Authors:  Luiza M F Gomes; Atif Mahammed; Kathleen E Prosser; Jason R Smith; Michael A Silverman; Charles J Walsby; Zeev Gross; Tim Storr
Journal:  Chem Sci       Date:  2018-12-03       Impact factor: 9.825
  3 in total

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