Literature DB >> 28110810

Biased Opioid Receptor Ligands: Gain without Pain.

Ravi Ranjan1, Shubhi Pandey1, Arun K Shukla2.   

Abstract

Kappa opioid receptor (κ-OR) agonists are promising therapeutic candidates for pain and itch; however, they also exhibit the adverse effects of sedation and dysphoria. A recent study has demonstrated that a G protein-biased agonist for κ-OR provides effective pain and itch relief without causing sedation or dysphoria, in animal models.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28110810     DOI： 10.1016/j.tem.2017.01.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  7 in total

1.  Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.

Authors:  Anika Mann; Lionel Moulédous; Carine Froment; Patrick R O'Neill; Pooja Dasgupta; Thomas Günther; Gloria Brunori; Brigitte L Kieffer; Lawrence Toll; Michael R Bruchas; Nurulain T Zaveri; Stefan Schulz
Journal:  Sci Signal       Date:  2019-03-26       Impact factor: 8.192

2.  Biased Opioid Receptor Ligands: Gain without Pain.

Authors:  Tyler C Beck; Thomas A Dix; Russell A Norris
Journal:  Trends Endocrinol Metab       Date:  2020-09-14       Impact factor: 12.015

Review 3.  Structural insights into ligand recognition and activation of angiotensin receptors.

Authors:  Haitao Zhang; Aleksandra Luginina; Alexey Mishin; Mithu Baidya; Arun K Shukla; Vadim Cherezov
Journal:  Trends Pharmacol Sci       Date:  2021-05-10       Impact factor: 14.819

Review 4.  The Mechanisms Involved in Morphine Addiction: An Overview.

Authors:  Joanna Listos; Małgorzata Łupina; Sylwia Talarek; Antonina Mazur; Jolanta Orzelska-Górka; Jolanta Kotlińska
Journal:  Int J Mol Sci       Date:  2019-09-03       Impact factor: 5.923

5.  Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.

Authors:  Shubhi Pandey; Punita Kumari; Mithu Baidya; Ryoji Kise; Yubo Cao; Hemlata Dwivedi-Agnihotri; Ramanuj Banerjee; Xaria X Li; Cedric S Cui; John D Lee; Kouki Kawakami; Jagannath Maharana; Ashutosh Ranjan; Madhu Chaturvedi; Gagan Deep Jhingan; Stéphane A Laporte; Trent M Woodruff; Asuka Inoue; Arun K Shukla
Journal:  Mol Cell       Date:  2021-09-27       Impact factor: 19.328

6.  Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2.

Authors:  Aetas Amponnawarat; Chalatip Chompunud Na Ayudhya; Hydar Ali
Journal:  Front Immunol       Date:  2021-06-23       Impact factor: 7.561

7.  Synthesis, Radiosynthesis and Biological Evaluation of Buprenorphine-Derived Phenylazocarboxamides as Novel μ-Opioid Receptor Ligands.

Authors:  Jasmin Krüll; Stefanie K Fehler; Laura Hofmann; Natascha Nebel; Simone Maschauer; Olaf Prante; Peter Gmeiner; Harald Lanig; Harald Hübner; Markus R Heinrich
Journal:  ChemMedChem       Date:  2020-06-02       Impact factor: 3.466
  7 in total

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