| Literature DB >> 28110409 |
Taiki Ando1, Etsuko Yamazaki2,3, Eriko Ogusa1, Yoshimi Ishii1, Wataru Yamamoto1, Kenji Motohashi1, Takayoshi Tachibana4, Maki Hagihara5, Kenji Matsumoto5, Masatsugu Tanaka4, Chizuko Hashimoto6, Hideyuki Koharazawa7, Katsumichi Fujimaki8, Jun Taguchi7, Hiroyuki Fujita9, Heiwa Kanamori4, Shin Fujisawa1, Hideaki Nakajima5.
Abstract
Body mass index (BMI), which represents the proportion of weight to height, is a controversial prognostic factor for acute myeloid leukemia (AML). We evaluated prognostic value of BMI in Japanese AML. The study included 369 adult patients with newly diagnosed AML who were administered either daunorubicin or idarubicin with cytarabine as induction chemotherapy. The patients were categorized into two groups according to their BMI: the NW group (BMI < 25.0 kg/m2; normal and underweight) and OW group (BMI ≥ 25.0 kg/m2; overweight and obese). We analyzed treatment efficacy and toxicity of induction chemotherapy, and survival outcomes in each group. Patients in the OW group showed a better complete remission rate than the NW group (86.1 versus 76.5%, P = 0.045), no early death (0.0 versus 4.1%, P = 0.042), and better overall survival (OS) at 3 years (62.2 versus 50.1%, P = 0.012). Multivariate analysis showed BMI is an independent prognostic factor for OS (hazard ratio 0.62, 95% confidence interval 0.42-0.92, P = 0.017). These results indicate the prognostic value of BMI in adult AML patients.Entities:
Keywords: Acute myeloid leukemia; Body mass index; Japanese; Obese
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Year: 2017 PMID： 28110409 DOI： 10.1007/s12185-017-2183-7
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490