Literature DB >> 28096549

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.

Yoshihiro Watanabe1, Takuya Suga2, Satomi Narusawa2, Masato Iwatsuki1,2, Kenichi Nonaka1,2, Takuji Nakashima1,2, Yasuo Shinohara3, Takahiro Shiotsuki4, Naoya Ichimaru5, Hideto Miyoshi6, Yukihiro Asami1,2, Satoshi Ōmura2, Kazuro Shiomi1,2.   

Abstract

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

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Year:  2017        PMID： 28096549     DOI： 10.1038/ja.2016.164

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

1.  Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae.

Authors:  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Ōmura; Kazuro Shiomi
Journal:  J Antibiot (Tokyo)       Date:  2015-05-06       Impact factor: 2.649

2.  Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system.

Authors:  Takumi Chinen; Yoko Nagumo; Takeo Usui
Journal:  J Gen Appl Microbiol       Date:  2014       Impact factor: 1.452

3.  [Mucidin, the first Czechoslovakian antibiotic].

Authors:  P Ago
Journal:  Minerva Med       Date:  1970-09-25       Impact factor: 4.806

Review 4.  Review of strobilurin fungicide chemicals.

Authors:  Hamdy Balba
Journal:  J Environ Sci Health B       Date:  2007-05       Impact factor: 1.990

5.  Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.

Authors:  T Friedrich; P van Heek; H Leif; T Ohnishi; E Forche; B Kunze; R Jansen; W Trowitzsch-Kienast; G Höfle; H Reichenbach
Journal:  Eur J Biochem       Date:  1994-01-15

6.  Ca2+-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions.

Authors:  Akiko Yamada; Takenori Yamamoto; Yuya Yoshimura; Shunichi Gouda; Satoshi Kawashima; Naoshi Yamazaki; Kikuji Yamashita; Masatoshi Kataoka; Toshihiko Nagata; Hiroshi Terada; Douglas R Pfeiffer; Yasuo Shinohara
Journal:  Biochim Biophys Acta       Date:  2009-07-16

7.  Pyrimidifen intoxication.

Authors:  Miruna Eisinger; Yaniv Almog
Journal:  Ann Emerg Med       Date:  2003-08       Impact factor: 5.721

8.  Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system.

Authors:  Takuya Suga; Yukihiro Asami; Shohei Hashimoto; Kenichi Nonaka; Masato Iwatsuki; Takuji Nakashima; Yoshihiro Watanabe; Ryohei Sugahara; Takahiro Shiotsuki; Takenori Yamamoto; Yasuo Shinohara; Naoya Ichimaru; Masatoshi Murai; Hideto Miyoshi; Satoshi Ōmura; Kazuro Shiomi
Journal:  J Gen Appl Microbiol       Date:  2015       Impact factor: 1.452

9.  Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae).

Authors:  Yupei Shan; Lingling Xu; Yang Lu; Xiaobing Wang; Qitai Zheng; Lingyi Kong; Masatake Niwa
Journal:  Chem Pharm Bull (Tokyo)       Date:  2008-01       Impact factor: 1.645

10.  Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A.

Authors:  Yuji Miyamoto; Kiyotaka Machida; Masaki Mizunuma; Yuji Emoto; Naomi Sato; Kohji Miyahara; Dai Hirata; Takeo Usui; Hidetoshi Takahashi; Hiroyuki Osada; Tokichi Miyakawa
Journal:  J Biol Chem       Date:  2002-06-05       Impact factor: 5.157
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  2 in total

1.  Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.

Authors:  Jee Whu Lee; Tee Gee Ong; Mohammed Razip Samian; Aik-Hong Teh; Nobumoto Watanabe; Hiroyuki Osada; Eugene Boon Beng Ong
Journal:  Sci Rep       Date:  2021-12-17       Impact factor: 4.379

2.  Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria.

Authors:  Katsuyuki Sakai; Yufu Unten; Aoi Kimishima; Kenichi Nonaka; Takumi Chinen; Kazunari Sakai; Takeo Usui; Kazuro Shiomi; Masato Iwatsuki; Masatoshi Murai; Hideto Miyoshi; Yukihiro Asami; Satoshi Ōmura
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258
  2 in total

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