Literature DB >> 28096153

Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions.

Guillermo Martín-Gutiérrez1,2, José Manuel Rodríguez-Martínez1,3, Álvaro Pascual1,3,2, Jerónimo Rodríguez-Beltrán4, Jesús Blázquez4,2,5.   

Abstract

Escherichia coli variants expressing plasmid-mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Escherichia coli; MIC; ciprofloxacin; pH; qnr; urinary tract infection

Mesh：

Substances：

Year:  2017        PMID： 28096153      PMCID： PMC5365700          DOI： 10.1128/AAC.02615-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

Review 1.  Resistance plasmid families in Enterobacteriaceae.

Authors:  Alessandra Carattoli
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

2.  Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.

Authors:  Ari Robicsek; Jacob Strahilevitz; George A Jacoby; Mark Macielag; Darren Abbanat; Chi Hye Park; Karen Bush; David C Hooper
Journal:  Nat Med       Date:  2005-12-20       Impact factor: 53.440

Review 3.  Resistance in gram-negative bacteria: enterobacteriaceae.

Authors:  David L Paterson
Journal:  Am J Med       Date:  2006-06       Impact factor: 4.965

4.  Antibiotic use in Dutch primary care: relation between diagnosis, consultation and treatment.

Authors:  Joep van den Broek d'Obrenan; Theo J M Verheij; Mattijs E Numans; Alike W van der Velden
Journal:  J Antimicrob Chemother       Date:  2014-02-06       Impact factor: 5.790

5.  Risk factors for fluoroquinolone-resistant Escherichia coli in adults with community-onset febrile urinary tract infection.

Authors:  Willize E van der Starre; Cees van Nieuwkoop; Sunita Paltansing; Jan W van't Wout; Geert H Groeneveld; Martin J Becker; Ted Koster; G Hanke Wattel-Louis; Nathalie M Delfos; Hans C Ablij; Eliane M S Leyten; Jeanet W Blom; Jaap T van Dissel
Journal:  J Antimicrob Chemother       Date:  2010-12-01       Impact factor: 5.790

Review 6.  Low-level antibacterial resistance: a gateway to clinical resistance.

Authors:  F Baquero
Journal:  Drug Resist Updat       Date:  2001-04       Impact factor: 18.500

7.  Genetic characterization of fluoroquinolone resistant Escherichia coli from urban streams and municipal and hospital effluents.

Authors:  Ana Rita Varela; Gonçalo N Macedo; Olga C Nunes; Célia M Manaia
Journal:  FEMS Microbiol Ecol       Date:  2015-02-11       Impact factor: 4.194

8.  Plasmid-mediated quinolone resistance genes, aac(6')-Ib-cr, qnrS, qnrB, and qnrA, in urinary isolates of Escherichia coli and Klebsiella pneumoniae at a teaching hospital, Thailand.

Authors:  Woravit Pasom; Aroonwadee Chanawong; Aroonlug Lulitanond; Chotechana Wilailuckana; Suthida Kenprom; Pirom Puang-Ngern
Journal:  Jpn J Infect Dis       Date:  2013       Impact factor: 1.362

9.  Urinary Tract Physiological Conditions Promote Ciprofloxacin Resistance in Low-Level-Quinolone-Resistant Escherichia coli.

Authors:  Guillermo Martín-Gutiérrez; Jerónimo Rodríguez-Beltrán; José Manuel Rodríguez-Martínez; Coloma Costas; Javier Aznar; Álvaro Pascual; Jesús Blázquez
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

Review 10.  Plasmid-mediated quinolone resistance: a multifaceted threat.

Authors:  Jacob Strahilevitz; George A Jacoby; David C Hooper; Ari Robicsek
Journal:  Clin Microbiol Rev       Date:  2009-10       Impact factor: 26.132
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  2 in total

1.  Urinary Tract Conditions Affect Fosfomycin Activity against Escherichia coli Strains Harboring Chromosomal Mutations Involved in Fosfomycin Uptake.

Authors:  G Martín-Gutiérrez; F Docobo-Pérez; J Rodriguez-Beltrán; J M Rodríguez-Martínez; J Aznar; A Pascual; J Blázquez
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

2.  Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli.

Authors:  Linnéa Garoff; Kavita Yadav; Diarmaid Hughes
Journal:  J Antimicrob Chemother       Date:  2018-02-01       Impact factor: 5.790
  2 in total

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