Literature DB >> 28095368

Iron overload and altered iron metabolism in ovarian cancer.

Stephanie Rockfield1, Joseph Raffel1, Radhe Mehta1, Nabila Rehman1, Meera Nanjundan1.   

Abstract

Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.

Entities:  

Keywords:  endometriosis; fallopian tube fimbrial epithelium; microbiome; ovarian surface epithelium; therapy

Mesh：

Substances：

Year:  2017        PMID： 28095368      PMCID： PMC5545069          DOI： 10.1515/hsz-2016-0336

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  135 in total

Review 1.  Role of iron in neurodegenerative disorders.

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Journal:  Top Magn Reson Imaging       Date:  2006-02

Review 2.  Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.

Authors:  Yoshihiko Yamada; Hiroshi Shigetomi; Akira Onogi; Shoji Haruta; Ryuji Kawaguchi; Shozo Yoshida; Naoto Furukawa; Akira Nagai; Yasuhito Tanase; Taihei Tsunemi; Hidekazu Oi; Hiroshi Kobayashi
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3.  High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats.

Authors:  T Tanaka; Y Iwasa; S Kondo; H Hiai; S Toyokuni
Journal:  Oncogene       Date:  1999-06-24       Impact factor: 9.867

Review 4.  Role of iron in estrogen-induced cancer.

Authors:  J G Liehr; J S Jones
Journal:  Curr Med Chem       Date:  2001-06       Impact factor: 4.530

5.  Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses.

Authors:  Fan Zhang; Yunlong Tao; Zhuzhen Zhang; Xin Guo; Peng An; Yuanyuan Shen; Qian Wu; Yu Yu; Fudi Wang
Journal:  Haematologica       Date:  2012-06-11       Impact factor: 9.941

6.  Ferroptosis as a p53-mediated activity during tumour suppression.

Authors:  Le Jiang; Ning Kon; Tongyuan Li; Shang-Jui Wang; Tao Su; Hanina Hibshoosh; Richard Baer; Wei Gu
Journal:  Nature       Date:  2015-03-18       Impact factor: 49.962

7.  Fimbrial cells exposure to catalytic iron mimics carcinogenic changes.

Authors:  Debora Lattuada; Francesca Uberti; Barbara Colciaghi; Vera Morsanuto; Elena Maldi; Diletta Francesca Squarzanti; Claudio Molinari; Renzo Boldorini; Alessandro Bulfoni; Paola Colombo; Giorgio Bolis
Journal:  Int J Gynecol Cancer       Date:  2015-03       Impact factor: 3.437

8.  A cytosolic iron chaperone that delivers iron to ferritin.

Authors:  Haifeng Shi; Krisztina Z Bencze; Timothy L Stemmler; Caroline C Philpott
Journal:  Science       Date:  2008-05-30       Impact factor: 47.728

9.  Dietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk.

Authors:  Noortje IJssennagger; Muriel Derrien; Gerdien M van Doorn; Anneke Rijnierse; Bartholomeus van den Bogert; Michael Müller; Jan Dekker; Michiel Kleerebezem; Roelof van der Meer
Journal:  PLoS One       Date:  2012-12-11       Impact factor: 3.240

Review 10.  Iron deprivation in cancer--potential therapeutic implications.

Authors:  Jessica L Heath; Joshua M Weiss; Catherine P Lavau; Daniel S Wechsler
Journal:  Nutrients       Date:  2013-07-24       Impact factor: 5.717
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  10 in total

1.  Dietary iron to total energy intake ratio and type 2 diabetes incidence in a longitudinal 12-year analysis of the Korean Genome and Epidemiology Cohort Study.

Authors:  Dong-Hyuk Jung; Kyeng Won Hong; Byoungjin Park; Yong-Jae Lee
Journal:  Eur J Nutr       Date:  2021-06-03       Impact factor: 5.614

2.  A Robust and Versatile Automated Glycoanalytical Technology for Serum Antibodies and Acute Phase Proteins: Ovarian Cancer Case Study.

Authors:  Róisín O'Flaherty; Mohankumar Muniyappa; Ian Walsh; Henning Stöckmann; Mark Hilliard; Richard Hutson; Radka Saldova; Pauline M Rudd
Journal:  Mol Cell Proteomics       Date:  2019-08-30       Impact factor: 5.911

3.  Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells.

Authors:  Ravneet Chhabra; Stephanie Rockfield; Jennifer Guergues; Owen W Nadeau; Robert Hill; Stanley M Stevens; Meera Nanjundan
Journal:  Sci Rep       Date:  2021-03-18       Impact factor: 4.379

4.  Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells.

Authors:  Yu-Shien Sung; Baris Kerimoglu; Aikseng Ooi; Elisa Tomat
Journal:  ACS Med Chem Lett       Date:  2022-08-18       Impact factor: 4.632

5.  Heterogeneity of ferrous iron-containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns.

Authors:  Peter W Halcrow; Nirmal Kumar; Zahra Afghah; Jalyn P Fischer; Nabab Khan; Xuesong Chen; Olimpia Meucci; Jonathan D Geiger
Journal:  J Neurochem       Date:  2022-02-23       Impact factor: 5.546

6.  The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy.

Authors:  Shoichiro Yamanaka; Naoki Kawahara; Ryuji Kawaguchi; Keita Waki; Tomoka Maehana; Yosuke Fukui; Ryuta Miyake; Yuki Yamada; Hiroshi Kobayashi; Fuminori Kimura
Journal:  Diagnostics (Basel)       Date:  2022-05-12

Review 7.  Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review.

Authors:  Liudmila M Mikhaleva; Aleksandr I Davydov; Olga I Patsap; Elizaveta V Mikhaylenko; Vladimir N Nikolenko; Margarita E Neganova; Sergey G Klochkov; Siva G Somasundaram; Cecil E Kirkland; Gjumrakch Aliev
Journal:  Adv Ther       Date:  2020-05-08       Impact factor: 3.845

Review 8.  Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.

Authors:  Josep Marí-Alexandre; Antonio Pellín Carcelén; Cristina Agababyan; Andrea Moreno-Manuel; Javier García-Oms; Silvia Calabuig-Fariñas; Juan Gilabert-Estellés
Journal:  Int J Mol Sci       Date:  2019-10-25       Impact factor: 5.923

Review 9.  Current progress of ferroptosis study in ovarian cancer.

Authors:  Zhuomin Tan; Hui Huang; Wenyan Sun; Ya Li; Yinnong Jia
Journal:  Front Mol Biosci       Date:  2022-08-26

Review 10.  Links Between Iron and Lipids: Implications in Some Major Human Diseases.

Authors:  Stephanie Rockfield; Ravneet Chhabra; Michelle Robertson; Nabila Rehman; Richa Bisht; Meera Nanjundan
Journal:  Pharmaceuticals (Basel)       Date:  2018-10-22
  10 in total

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