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Literature DB >> 28094476

DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.

Abstract

"… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …" Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.

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Substances：

Year: 2017 PMID： 28094476 DOI： 10.1002/anie.201612143

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

18 in total

1. Multistep Synthesis of 1,2,4-Oxadiazoles via DNA-Conjugated Aryl Nitrile Substrates.

Authors: Huang-Chi Du; Madison C Bangs; Nicholas Simmons; Martin M Matzuk
Journal: Bioconjug Chem Date: 2019-04-10 Impact factor: 4.774

2. Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells.

Authors: Bo Cai; Dongwook Kim; Saeed Akhand; Yixing Sun; Robert J Cassell; Aktan Alpsoy; Emily C Dykhuizen; Richard M Van Rijn; Michael K Wendt; Casey J Krusemark
Journal: J Am Chem Soc Date: 2019-10-22 Impact factor: 15.419

3. Kinetically guided radical-based synthesis of C(sp³)-C(sp³) linkages on DNA.

Authors: Jie Wang; Helena Lundberg; Shota Asai; Pedro Martín-Acosta; Jason S Chen; Stephen Brown; William Farrell; Russell G Dushin; Christopher J O'Donnell; Anokha S Ratnayake; Paul Richardson; Zhiqing Liu; Tian Qin; Donna G Blackmond; Phil S Baran
Journal: Proc Natl Acad Sci U S A Date: 2018-06-26 Impact factor: 11.205

4. Antibody selection using clonal cocultivation of Escherichia coli and eukaryotic cells in miniecosystems.

Authors: Tianqing Zheng; Jia Xie; Zhuo Yang; Pingdong Tao; Bingbing Shi; Lacey Douthit; Peng Wu; Richard A Lerner
Journal: Proc Natl Acad Sci U S A Date: 2018-06-18 Impact factor: 11.205

5. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.

Authors: Dillon T Flood; Xuejing Zhang; Xiang Fu; Zhenxiang Zhao; Shota Asai; Brittany B Sanchez; Emily J Sturgell; Julien C Vantourout; Paul Richardson; Mark E Flanagan; David W Piotrowski; Dominik K Kölmel; Jinqiao Wan; Mei-Hsuan Tsai; Jason S Chen; Phil S Baran; Philip E Dawson
Journal: Angew Chem Int Ed Engl Date: 2020-03-11 Impact factor: 15.336

6. Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF₄ )-Derived Connective Hubs for Bioconjugation to DNA and Proteins.

Authors: Feng Liu; Hua Wang; Suhua Li; Grant A L Bare; Xuemin Chen; Chu Wang; John E Moses; Peng Wu; K Barry Sharpless
Journal: Angew Chem Int Ed Engl Date: 2019-05-08 Impact factor: 15.336

Review 7. DNA-encoded chemical libraries - achievements and remaining challenges.

Authors: Nicholas Favalli; Gabriele Bassi; Jörg Scheuermann; Dario Neri
Journal: FEBS Lett Date: 2018-05-10 Impact factor: 4.124

8. A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library.

Authors: Gunther Zimmermann; Ulrike Rieder; Davor Bajic; Sara Vanetti; Apirat Chaikuad; Stefan Knapp; Jörg Scheuermann; Martin Mattarella; Dario Neri
Journal: Chemistry Date: 2017-05-30 Impact factor: 5.236

9. Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold.

Authors: Yizhou Li; Roberto De Luca; Samuele Cazzamalli; Francesca Pretto; Davor Bajic; Jörg Scheuermann; Dario Neri
Journal: Nat Chem Date: 2018-03-19 Impact factor: 24.427

10. Merging C(sp³)-H activation with DNA-encoding.

Authors: Zhoulong Fan; Shuai Zhao; Tao Liu; Peng-Xiang Shen; Zi-Ning Cui; Zhe Zhuang; Qian Shao; Jason S Chen; Anokha S Ratnayake; Mark E Flanagan; Dominik K Kölmel; David W Piotrowski; Paul Richardson; Jin-Quan Yu
Journal: Chem Sci Date: 2020-09-07 Impact factor: 9.825