Literature DB >> 28090581

Two-faced activity of RNF8: What "twists" it from a genome guardian to a cancer facilitator?

Hong-Jen Lee1, Diane Ruan1, Jiabei He1, Chia-Hsin Chan1.   

Abstract

The RING finger protein 8 (RNF8)-induced ubiquitination signaling cascade promotes DNA repair and maintains genomic stability. Our study reveals an unexpected action of RNF8 in promoting cancer metastasis, cancer stem cell formation, and chemoresistance through the regulation of TWIST lysine 63 (K63)-linked ubiquitination, suggesting that RNF8 may serve as a new cancer prognosis marker and therapeutic target.

Entities:  

Keywords:  Metastasis; RNF8; TWIST; triple-negative breast cancer

Year:  2016        PMID： 28090581      PMCID： PMC5160391          DOI： 10.1080/23723556.2016.1242454

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Triple-negative breast cancer: clinical features and patterns of recurrence.

Authors:  Rebecca Dent; Maureen Trudeau; Kathleen I Pritchard; Wedad M Hanna; Harriet K Kahn; Carol A Sawka; Lavina A Lickley; Ellen Rawlinson; Ping Sun; Steven A Narod
Journal:  Clin Cancer Res       Date:  2007-08-01       Impact factor: 12.531

2.  RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Authors:  Michael S Y Huen; Robert Grant; Isaac Manke; Kay Minn; Xiaochun Yu; Michael B Yaffe; Junjie Chen
Journal:  Cell       Date:  2007-11-20       Impact factor: 41.582

3.  DNA-damage response and repair activities at uncapped telomeres depend on RNF8.

Authors:  Marieke H Peuscher; Jacqueline J L Jacobs
Journal:  Nat Cell Biol       Date:  2011-08-21       Impact factor: 28.824

4.  Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.

Authors:  Alexandre Orthwein; Amélie Fradet-Turcotte; Sylvie M Noordermeer; Marella D Canny; Catherine M Brun; Jonathan Strecker; Cristina Escribano-Diaz; Daniel Durocher
Journal:  Science       Date:  2014-03-20       Impact factor: 47.728

5.  The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation.

Authors:  Hong-Jen Lee; Chien-Feng Li; Diane Ruan; Scott Powers; Patricia A Thompson; Michael A Frohman; Chia-Hsin Chan
Journal:  Mol Cell       Date:  2016-09-08       Impact factor: 17.970

6.  Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

Authors:  Chia-Hsin Chan; John Kenneth Morrow; Chien-Feng Li; Yuan Gao; Guoxiang Jin; Asad Moten; Loren J Stagg; John E Ladbury; Zhen Cai; Dazhi Xu; Christopher J Logothetis; Mien-Chie Hung; Shuxing Zhang; Hui-Kuan Lin
Journal:  Cell       Date:  2013-08-01       Impact factor: 41.582

7.  Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Authors:  Tina Thorslund; Anita Ripplinger; Saskia Hoffmann; Thomas Wild; Michael Uckelmann; Bine Villumsen; Takeo Narita; Titia K Sixma; Chunaram Choudhary; Simon Bekker-Jensen; Niels Mailand
Journal:  Nature       Date:  2015-10-21       Impact factor: 49.962

8.  The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

Authors:  Rekha Rai; Ju-Mei Li; Hong Zheng; Gabriel Tsz-Mei Lok; Yu Deng; Michael S-Y Huen; Junjie Chen; Jianping Jin; Sandy Chang
Journal:  Nat Struct Mol Biol       Date:  2011-11-20       Impact factor: 18.361

9.  EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.

Authors:  Anne-Pierre Morel; George W Hinkal; Clémence Thomas; Frédérique Fauvet; Stéphanie Courtois-Cox; Anne Wierinckx; Mojgan Devouassoux-Shisheboran; Isabelle Treilleux; Agnès Tissier; Baptiste Gras; Julie Pourchet; Isabelle Puisieux; Gareth J Browne; Douglas B Spicer; Joël Lachuer; Stéphane Ansieau; Alain Puisieux
Journal:  PLoS Genet       Date:  2012-05-24       Impact factor: 5.917

10.  RNF8 promotes epithelial-mesenchymal transition of breast cancer cells.

Authors:  Jingyu Kuang; Li Li; Limei Guo; Yanrong Su; Yuxuan Wang; Yongjie Xu; Xiaozhen Wang; Shucong Meng; Liandi Lei; Luzheng Xu; Genze Shao
Journal:  J Exp Clin Cancer Res       Date:  2016-06-04
  10 in total
  5 in total

1.  Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.

Authors:  Jiabei He; Hong-Jen Lee; Suchandrima Saha; Diane Ruan; Hua Guo; Chia-Hsin Chan
Journal:  Cell Death Dis       Date:  2019-03-28       Impact factor: 8.469

2.  The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.

Authors:  Abhay Narayan Singh; Judith Oehler; Ignacio Torrecilla; Susan Kilgas; Shudong Li; Bruno Vaz; Claire Guérillon; John Fielden; Esperanza Hernandez-Carralero; Elisa Cabrera; Iain Dc Tullis; Mayura Meerang; Paul R Barber; Raimundo Freire; Jason Parsons; Borivoj Vojnovic; Anne E Kiltie; Niels Mailand; Kristijan Ramadan
Journal:  EMBO J       Date:  2019-10-15       Impact factor: 11.598

3.  Bioinformatic Identification of miR-622 Key Target Genes and Experimental Validation of the miR-622-RNF8 Axis in Breast Cancer.

Authors:  Chuanyang Liu; Lu Min; Jingyu Kuang; Chushu Zhu; Xin-Yuan Qiu; Lingyun Zhu
Journal:  Front Oncol       Date:  2019-10-23       Impact factor: 6.244

4.  Comprehensive Analysis of hsa-miR-654-5p's Tumor-Suppressing Functions.

Authors:  Chuanyang Liu; Lu Min; Jingyu Kuang; Chushu Zhu; Xinyuan Qiu; Xiaomin Wu; Tianyi Zhang; Sisi Xie; Lingyun Zhu
Journal:  Int J Mol Sci       Date:  2022-06-08       Impact factor: 6.208

5.  The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells.

Authors:  Bruno Pereira De Carvalho; Yi-Jye Chern; Jiabei He; Chia-Hsin Chan
Journal:  FEBS Lett       Date:  2020-12-05       Impact factor: 4.124
  5 in total

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