Literature DB >> 28090580

Tumors smother their epigenome.

Bernard Thienpont1, Laurien Van Dyck1, Diether Lambrechts1.   

Abstract

DNA hypermethylation is pervasive in tumors, but the factors triggering this modification are largely unknown. We recently demonstrated that the activity of 10-11-translocation methylcytosine dioxygenases, initiators of DNA demethylation, is compromised in hypoxic tumors. The resultant accumulation of methylation inactivates associated genes, linking the tumor microenvironment to epigenetic changes in cancer cells.

Entities:  

Keywords:  5-hydroxymethylcytosine; 5-methylcytosine; DNA hypermethylation; Hypoxia; TET1; TET2; TET3; oncogenesis

Year:  2016        PMID： 28090580      PMCID： PMC5160384          DOI： 10.1080/23723556.2016.1240549

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Epigenetics in cancer.

Authors:  Manel Esteller
Journal:  N Engl J Med       Date:  2008-03-13       Impact factor: 91.245

2.  The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Authors:  Anna Kuchnio; Stijn Moens; Ulrike Bruning; Karol Kuchnio; Bert Cruys; Bernard Thienpont; Michaël Broux; Andreea Alexandra Ungureanu; Rodrigo Leite de Oliveira; Françoise Bruyère; Henar Cuervo; Ann Manderveld; An Carton; Juan Ramon Hernandez-Fernaud; Sara Zanivan; Carmen Bartic; Jean-Michel Foidart; Agnes Noel; Stefan Vinckier; Diether Lambrechts; Mieke Dewerchin; Massimiliano Mazzone; Peter Carmeliet
Journal:  Cell Rep       Date:  2015-07-30       Impact factor: 9.423

3.  DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature.

Authors:  Els Wauters; Wim Janssens; Johan Vansteenkiste; Herbert Decaluwé; Nele Heulens; Bernard Thienpont; Hui Zhao; Dominiek Smeets; Xavier Sagaert; Johan Coolen; Marc Decramer; Adrian Liston; Paul De Leyn; Matthieu Moisse; Diether Lambrechts
Journal:  Thorax       Date:  2015-09-08       Impact factor: 9.139

Review 4.  Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

Authors:  Miguel R Branco; Gabriella Ficz; Wolf Reik
Journal:  Nat Rev Genet       Date:  2011-11-15       Impact factor: 53.242

Review 5.  OH, the Places You'll Go! Hydroxylation, Gene Expression, and Cancer.

Authors:  Athanasios Ploumakis; Mathew L Coleman
Journal:  Mol Cell       Date:  2015-06-04       Impact factor: 17.970

6.  TET proteins and the control of cytosine demethylation in cancer.

Authors:  Laurianne Scourzic; Enguerran Mouly; Olivier A Bernard
Journal:  Genome Med       Date:  2015-01-29       Impact factor: 11.117

7.  Tumour hypoxia causes DNA hypermethylation by reducing TET activity.

Authors:  Bernard Thienpont; Jessica Steinbacher; Hui Zhao; Flora D'Anna; Anna Kuchnio; Athanasios Ploumakis; Bart Ghesquière; Laurien Van Dyck; Bram Boeckx; Luc Schoonjans; Els Hermans; Frederic Amant; Vessela N Kristensen; Kian Peng Koh; Massimiliano Mazzone; Mathew Coleman; Thomas Carell; Peter Carmeliet; Diether Lambrechts
Journal:  Nature       Date:  2016-08-17       Impact factor: 49.962

8.  Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress.

Authors:  Benjamin Delatte; Jana Jeschke; Matthieu Defrance; Martin Bachman; Catherine Creppe; Emilie Calonne; Martin Bizet; Rachel Deplus; Laura Marroquí; Myriam Libin; Mirunalini Ravichandran; Françoise Mascart; Decio L Eizirik; Adele Murrell; Tomasz P Jurkowski; François Fuks
Journal:  Sci Rep       Date:  2015-08-04       Impact factor: 4.379

9.  Mutational landscape and significance across 12 major cancer types.

Authors:  Cyriac Kandoth; Michael D McLellan; Fabio Vandin; Kai Ye; Beifang Niu; Charles Lu; Mingchao Xie; Qunyuan Zhang; Joshua F McMichael; Matthew A Wyczalkowski; Mark D M Leiserson; Christopher A Miller; John S Welch; Matthew J Walter; Michael C Wendl; Timothy J Ley; Richard K Wilson; Benjamin J Raphael; Li Ding
Journal:  Nature       Date:  2013-10-17       Impact factor: 49.962

10.  Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.

Authors:  Kathryn Blaschke; Kevin T Ebata; Mohammad M Karimi; Jorge A Zepeda-Martínez; Preeti Goyal; Sahasransu Mahapatra; Angela Tam; Diana J Laird; Martin Hirst; Anjana Rao; Matthew C Lorincz; Miguel Ramalho-Santos
Journal:  Nature       Date:  2013-06-30       Impact factor: 49.962
  10 in total
  1 in total

Review 1.  Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?

Authors:  Ekaterina M Zhidkova; Evgeniya S Lylova; Diana D Grigoreva; Kirill I Kirsanov; Alena V Osipova; Evgeny P Kulikov; Sergey A Mertsalov; Gennady A Belitsky; Irina Budunova; Marianna G Yakubovskaya; Ekaterina A Lesovaya
Journal:  Int J Mol Sci       Date:  2022-08-26       Impact factor: 6.208
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.