Fabio Raneri1, Maria Angela Samis Zella2, Andrea Di Cristofori3, Barbara Zarino4, Mauro Pluderi4, Diego Spagnoli5. 1. Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy; Department of Neurosurgery, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: fabran@gmail.com. 2. Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy; Department of Neurology, Ruhr-University Bochum, Bochum, Germany. 3. Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy; Department of Neurosurgery, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: andrea.dicristofori@gmail.com. 4. Department of Neurosurgery, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. 5. Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy; Department of Neurosurgery, Ospedale Classificato "MoriggiaPelascini", Gravedona, Como, Italy.
Abstract
BACKGROUND: The lumbar infusion test (LIT) and tap test (TT) have previously been described for the diagnosis and selection of appropriate surgical candidates in idiopathic normal pressure hydrocephalus (iNPH). METHODS: We retrospectively reviewed 81 consecutive patients with a clinical diagnosis of iNPH selected for supplementary testing. Clinical evaluation was scored with the Japanese Grading Scale for Normal Pressure Hydrocephalus, the Global Deterioration Score, and the modified Rankin Scale (mRS). The test protocol included a cerebrospinal fluid pressure monitoring (PMi), an LIT, and a TT. Patients were selected for surgery if outflow resistance was ≥14 mm Hg/mL/minute or if a clinical improvement was recorded after TT. RESULTS: Sixty-eight patients were selected for ventriculoperitoneal shunting; 72.8% had a positive PMi or LIT, 74.1% had a positive TT, and 63.0% were positive to both tests. Complications were all transient. Clinical evaluation at 12 months after shunting showed a global improvement in 60 patients (88.2%). Overall, 75.0% of patients had no significant disability (mRS score, 1 and 2), 20.6% had an mRS score of 3 or 4, and 4.4% had severe disability after surgery. The positive predictive value of PMi/LIT, TT, or both combined was similar (89.8, 90.0, and 88.2%); however, 21.7% of patients who improved after surgery were selected with either a positive LIT or TT alone. CONCLUSIONS: LIT and TT are complementary and they can easily be combined in sequence with a low complication rate and high probability of selecting patients with iNPH who may benefit from ventriculoperitoneal shunt surgery.
BACKGROUND: The lumbar infusion test (LIT) and tap test (TT) have previously been described for the diagnosis and selection of appropriate surgical candidates in idiopathic normal pressure hydrocephalus (iNPH). METHODS: We retrospectively reviewed 81 consecutive patients with a clinical diagnosis of iNPH selected for supplementary testing. Clinical evaluation was scored with the Japanese Grading Scale for Normal Pressure Hydrocephalus, the Global Deterioration Score, and the modified Rankin Scale (mRS). The test protocol included a cerebrospinal fluid pressure monitoring (PMi), an LIT, and a TT. Patients were selected for surgery if outflow resistance was ≥14 mm Hg/mL/minute or if a clinical improvement was recorded after TT. RESULTS: Sixty-eight patients were selected for ventriculoperitoneal shunting; 72.8% had a positive PMi or LIT, 74.1% had a positive TT, and 63.0% were positive to both tests. Complications were all transient. Clinical evaluation at 12 months after shunting showed a global improvement in 60 patients (88.2%). Overall, 75.0% of patients had no significant disability (mRS score, 1 and 2), 20.6% had an mRS score of 3 or 4, and 4.4% had severe disability after surgery. The positive predictive value of PMi/LIT, TT, or both combined was similar (89.8, 90.0, and 88.2%); however, 21.7% of patients who improved after surgery were selected with either a positive LIT or TT alone. CONCLUSIONS: LIT and TT are complementary and they can easily be combined in sequence with a low complication rate and high probability of selecting patients with iNPH who may benefit from ventriculoperitoneal shunt surgery.
Authors: M W T van Bilsen; L van den Abbeele; V Volovici; H D Boogaarts; R H M A Bartels; E J van Lindert Journal: Acta Neurochir (Wien) Date: 2022-05-30 Impact factor: 2.816
Authors: A Junkkari; A J Luikku; N Danner; H K Jyrkkänen; T Rauramaa; V E Korhonen; A M Koivisto; O Nerg; M Kojoukhova; T J Huttunen; J E Jääskeläinen; V Leinonen Journal: Fluids Barriers CNS Date: 2019-07-25
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