Xuesen Xing1, Xuhua Guan1, Li Liu1, Junqiang Xu1, Guoming Li1, Jianbo Zhan1, Gongping Liu1, Xiaoqing Jiang1, Xingfu Shen1, Yongzhong Jiang1, Yang Wu1, Hao Zhang2, Jing Huang3, Fan Ding4, Sha Sha1, Man Liu1, Faxian Zhan5. 1. Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2). 2. Yichang City Center for Disease Control and Prevention, Yichang, China(3). 3. Enshi County Center for Disease Control and Prevention, Enshi, China(4). 4. Chinese Center for Disease Control and Prevention, Beijing, China(5). 5. Hubei Provincial Center for Disease Control and Prevention, Wuhan,China. No. 6 north Zhuodaoquan Road, Hongshan District, Wuhan City, Hubei Province, China(2). Electronic address: xxs29237155@163.com.
Abstract
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. METHODS: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSV patients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition. RESULTS: 68 cases and 136 controls participated in this study. In multivariate analysis, "Contact with cattle tick" was the major risk source (Conditional Logistic Regression OR-MH=8.62, 95% CI=1.79-41.51), outdoor activities and working in weeds or hillside fields could increase risk of cattle tick contact and SFTS infection (Conditional Logistic Regression OR-MH=8.82, 95% CI=1.69-46.05, P value=0.01). CONCLUSION: Our results suggested cattle might be dominant hosts in SFTS-endemic regions in Hubei Province, which provided clues to transmission mechanism of "vectors, host animals, and humans", thus more effectively preventing and controlling the disease.
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. METHODS: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSVpatients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition. RESULTS: 68 cases and 136 controls participated in this study. In multivariate analysis, "Contact with cattle tick" was the major risk source (Conditional Logistic Regression OR-MH=8.62, 95% CI=1.79-41.51), outdoor activities and working in weeds or hillside fields could increase risk of cattle tick contact and SFTS infection (Conditional Logistic Regression OR-MH=8.82, 95% CI=1.69-46.05, P value=0.01). CONCLUSION: Our results suggested cattle might be dominant hosts in SFTS-endemic regions in Hubei Province, which provided clues to transmission mechanism of "vectors, host animals, and humans", thus more effectively preventing and controlling the disease.
Authors: François Meurens; Charlotte Dunoyer; Christine Fourichon; Volker Gerdts; Nadia Haddad; Jeroen Kortekaas; Marta Lewandowska; Elodie Monchatre-Leroy; Artur Summerfield; Paul J Wichgers Schreur; Wim H M van der Poel; Jianzhong Zhu Journal: Animal Date: 2021-06-03 Impact factor: 3.240
Authors: Kwang-Min Yu; Su-Jin Park; Min-Ah Yu; Young-Il Kim; Younho Choi; Jae U Jung; Benjamin Brennan; Young Ki Choi Journal: Proc Natl Acad Sci U S A Date: 2019-12-09 Impact factor: 11.205