| Literature DB >> 28088312 |
Hasmet A Hanagasi1, Zeynep Tufekcioglu2, Murat Emre2.
Abstract
Dementia can occur in a substantial number of patients with Parkinson's disease with a point prevalence close to 30%. The cognitive profile is characterized by predominant deficits in executive, visuospatial functions, attention and memory. Behavioral symptoms are frequent such as apathy, visual hallucinations and delusions. The most prominent associated pathology is Lewy body-type and biochemical deficit is cholinergic. Placebo-controlled randomized trials with cholinesterase inhibitors demonstrated modest but significant benefits in cognition, behavioral symptoms and global functions.Entities:
Keywords: Cholinesterase inhibitors; Dementia; Dementia with Lewy Bodies; Parkinson's disease
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Year: 2017 PMID: 28088312 DOI: 10.1016/j.jns.2017.01.012
Source DB: PubMed Journal: J Neurol Sci ISSN: 0022-510X Impact factor: 3.181