| Literature DB >> 32741842 |
Wojciech Gryc1,2, Kathryn A Roberts1,2, Cyrus P Zabetian1,2, Daniel Weintraub3,4,5, John Q Trojanowski6,7, Joseph F Quinn8,9, Amie L Hiller8,9, Kathryn A Chung8,9, Kathleen L Poston10, Laurice Yang10, Shu-Ching Hu1,2, Karen L Edwards11, Thomas J Montine12, Brenna A Cholerton12.
Abstract
Neuropsychiatric symptoms are common in Parkinson's disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n = 696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p < 0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n = 444; p = 0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.Entities:
Keywords: Behavioral symptoms; Parkinson’s zzm321990disease; cognition; dementia; hallucinations
Year: 2020 PMID： 32741842 PMCID： PMC7609584 DOI： 10.3233/JPD-202116
Source DB: PubMed Journal: J Parkinsons Dis ISSN： 1877-7171 Impact factor: 5.568