Literature DB >> 30143749

Molecular mechanisms of viral oncogenesis in humans.

Nathan A Krump1, Jianxin You2.   

Abstract

Viral infection is a major contributor to the global cancer burden. Recent advances have revealed that seven known oncogenic viruses promote tumorigenesis through shared host cell targets and pathways. A comprehensive understanding of the principles of viral oncogenesis may enable the identification of unknown infectious aetiologies of cancer and the development of therapeutic or preventive strategies for virus-associated cancers. In this Review, we discuss the molecular mechanisms of viral oncogenesis in humans. We highlight recent advances in understanding how viral manipulation of host cellular signalling, DNA damage responses, immunity and microRNA targets promotes the initiation and development of cancer.

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Year:  2018        PMID： 30143749      PMCID： PMC6336458          DOI： 10.1038/s41579-018-0064-6

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  150 in total

1.  The papillomavirus E1 helicase activates a cellular DNA damage response in viral replication foci.

Authors:  Nozomi Sakakibara; Ruchira Mitra; Alison A McBride
Journal:  J Virol       Date:  2011-07-06       Impact factor: 5.103

Review 2.  Targeting the PI3K/Akt/mTOR pathway in malignancy: rationale and clinical outlook.

Authors:  Daniel C Cho
Journal:  BioDrugs       Date:  2014-08       Impact factor: 5.807

3.  Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.

Authors:  Amélie Fradet-Turcotte; Fanny Bergeron-Labrecque; Cary A Moody; Michaël Lehoux; Laimonis A Laimins; Jacques Archambault
Journal:  J Virol       Date:  2011-07-06       Impact factor: 5.103

4.  Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis.

Authors:  L Coscoy; D Ganem
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

5.  The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway.

Authors:  Christine C Tomlinson; Blossom Damania
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

6.  The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.

Authors:  Masahiro Fujimuro; S Diane Hayward
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

7.  KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Authors:  Fang Cheng; Pirita Pekkonen; Simonas Laurinavicius; Nami Sugiyama; Stephen Henderson; Thomas Günther; Ville Rantanen; Elisa Kaivanto; Mervi Aavikko; Grzegorz Sarek; Sampsa Hautaniemi; Peter Biberfeld; Lauri Aaltonen; Adam Grundhoff; Chris Boshoff; Kari Alitalo; Kaisa Lehti; Päivi M Ojala
Journal:  Cell Host Microbe       Date:  2011-12-15       Impact factor: 21.023

8.  Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.

Authors:  N Brimer; C Lyons; A E Wallberg; S B Vande Pol
Journal:  Oncogene       Date:  2012-01-16       Impact factor: 9.867

9.  Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis.

Authors:  Nicolas Rosewick; Keith Durkin; Maria Artesi; Ambroise Marçais; Vincent Hahaut; Philip Griebel; Natasa Arsic; Véronique Avettand-Fenoel; Arsène Burny; Carole Charlier; Olivier Hermine; Michel Georges; Anne Van den Broeke
Journal:  Nat Commun       Date:  2017-05-23       Impact factor: 14.919

10.  HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

Authors:  Keiko Yasuma; Jun-ichirou Yasunaga; Keiko Takemoto; Kenji Sugata; Yuichi Mitobe; Norihiro Takenouchi; Masanori Nakagawa; Yutaka Suzuki; Masao Matsuoka
Journal:  PLoS Pathog       Date:  2016-01-06       Impact factor: 6.823
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  37 in total

1.  Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes.

Authors:  Irene Lo Cigno; Federica Calati; Cinzia Borgogna; Alessandra Zevini; Silvia Albertini; Licia Martuscelli; Marco De Andrea; John Hiscott; Santo Landolfo; Marisa Gariglio
Journal:  J Virol       Date:  2020-01-31       Impact factor: 5.103

2.  HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement.

Authors:  Maciej T Nogalski; Thomas Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-30       Impact factor: 11.205

3.  Malignancy: An Adverse Effect of Immunosuppression.

Authors:  Mrudula Munagala; Anita Phancao
Journal:  Handb Exp Pharmacol       Date:  2022

4.  Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail.

Authors:  Yun-Ju Lai; Chi-Hong Chao; Chun-Che Liao; Te-An Lee; Jung-Mao Hsu; Wen-Cheng Chou; Jyun Wang; Hsiang-Chi Huang; Shing-Jyh Chang; Yi-Ling Lin; Chia-Wei Li
Journal:  Am J Cancer Res       Date:  2021-05-15       Impact factor: 6.166

Review 5.  Purinergic signaling and tumor microenvironment in cervical Cancer.

Authors:  Marta Schmidt Pfaffenzeller; Maria Luiza Mukai Franciosi; Andréia Machado Cardoso
Journal:  Purinergic Signal       Date:  2020-03-13       Impact factor: 3.765

6.  Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.

Authors:  Mohammad Alkhatib; Velia Chiara Di Maio; Valentina De Murtas; Ennio Polilli; Martina Milana; Elisabetta Teti; Gianluca Fiorentino; Vincenza Calvaruso; Silvia Barbaliscia; Ada Bertoli; Rossana Scutari; Luca Carioti; Valeria Cento; Maria Mercedes Santoro; Alessandro Orro; Ivana Maida; Ilaria Lenci; Loredana Sarmati; Antonio Craxì; Caterina Pasquazzi; Giustino Parruti; Sergio Babudieri; Luciano Milanesi; Massimo Andreoni; Mario Angelico; Carlo Federico Perno; Francesca Ceccherini-Silberstein; Valentina Svicher; Romina Salpini
Journal:  Viruses       Date:  2021-04-23       Impact factor: 5.048

Review 7.  Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update.

Authors:  Gulsum Ozlem Elpek
Journal:  World J Clin Cases       Date:  2021-07-06       Impact factor: 1.337

8.  High Seroprevalence of Hepatitis C Virus Antibody in Breast Cancer Patients in Egypt.

Authors:  Osama Hussein; Engy Mohamed El-Ghitany; Mawadda Omran; Ghadier Matariek; Esraa Ahmed Elbadaly; Rana Hamdy; Amira Gamal; Mai Mohamed Zayed; Ahmed Nasr; Omar Hamdy; Mohamed Elbasiony; Khaled Abdelwahab
Journal:  Breast Cancer (Auckl)       Date:  2021-03-24

Review 9.  Autophagy in Viral Development and Progression of Cancer.

Authors:  Alejandra Suares; María Victoria Medina; Omar Coso
Journal:  Front Oncol       Date:  2021-03-08       Impact factor: 6.244

Review 10.  Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis.

Authors:  Shimaa Hassan AbdelAziz Soliman; Arturo Orlacchio; Fabio Verginelli
Journal:  Microorganisms       Date:  2021-05-30
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