Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 SnapShot: Class 2 CRISPR-Cas Systems.

Literature DB >> 28086097

SnapShot: Class 2 CRISPR-Cas Systems.

Kira S Makarova¹, Feng Zhang², Eugene V Koonin¹.

Abstract

Class 2 CRISPR-Cas systems are characterized by effector modules consisting of single, large, multidomain proteins that appear to have been derived from mobile genetic elements. Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have been successfully repurposed for genome engineering. Published by Elsevier Inc.

Mesh：

Substances：
Endonucleases

Year: 2017 PMID： 28086097 DOI： 10.1016/j.cell.2016.12.038

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

50 in total

1. Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

Authors: Ning Jia; Charlie Y Mo; Chongyuan Wang; Edward T Eng; Luciano A Marraffini; Dinshaw J Patel
Journal: Mol Cell Date: 2018-11-29 Impact factor: 17.970

2. Multiple origins of reverse transcriptases linked to CRISPR-Cas systems.

Authors: Nicolás Toro; Francisco Martínez-Abarca; Mario Rodríguez Mestre; Alejandro González-Delgado
Journal: RNA Biol Date: 2019-07-11 Impact factor: 4.652

3. Second Messenger cA₄ Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

Authors: Ning Jia; Roger Jones; George Sukenick; Dinshaw J Patel
Journal: Mol Cell Date: 2019-07-17 Impact factor: 17.970

4. CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA₄ Cleavage with ApA>p Formation Terminating RNase Activity.

Authors: Ning Jia; Roger Jones; Guangli Yang; Ouathek Ouerfelli; Dinshaw J Patel
Journal: Mol Cell Date: 2019-07-17 Impact factor: 17.970

5. A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system.

Authors: Saifu Pan; Qi Li; Ling Deng; Suping Jiang; Xuexia Jin; Nan Peng; Yunxiang Liang; Qunxin She; Yingjun Li
Journal: RNA Biol Date: 2019-05-26 Impact factor: 4.652

Review 6. A decade of discovery: CRISPR functions and applications.

Authors: Rodolphe Barrangou; Philippe Horvath
Journal: Nat Microbiol Date: 2017-06-05 Impact factor: 17.745

Review 7. CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury.

Authors: Vera Paschon; Felipe Fernandes Correia; Beatriz Cintra Morena; Victor Allisson da Silva; Gustavo Bispo Dos Santos; Maria Cristina Carlan da Silva; Alexandre Fogaça Cristante; Stephanie Michelle Willerth; Florence Evelyne Perrin; Alexandre Hiroaki Kihara
Journal: Mol Neurobiol Date: 2020-01-11 Impact factor: 5.590

SnapShot: Class 2 CRISPR-Cas Systems.

1. Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

2. Multiple origins of reverse transcriptases linked to CRISPR-Cas systems.

3. Second Messenger cA₄ Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

4. CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA₄ Cleavage with ApA>p Formation Terminating RNase Activity.

5. A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system.

Review 6. A decade of discovery: CRISPR functions and applications.

Review 7. CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury.

Review 8. Advances toward Curing HIV-1 Infection in Tissue Reservoirs.

9. Directed evolution studies of a thermophilic Type II-C Cas9.

Review 10. Recent advances in the application of multiplex genome editing in Saccharomyces cerevisiae.

SnapShot: Class 2 CRISPR-Cas Systems.

1. Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.

2. Multiple origins of reverse transcriptases linked to CRISPR-Cas systems.

3. Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

4. CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity.

5. A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system.

Review 6. A decade of discovery: CRISPR functions and applications.

Review 7. CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury.

Review 8. Advances toward Curing HIV-1 Infection in Tissue Reservoirs.

9. Directed evolution studies of a thermophilic Type II-C Cas9.

Review 10. Recent advances in the application of multiplex genome editing in Saccharomyces cerevisiae.

3. Second Messenger cA₄ Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.

4. CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA₄ Cleavage with ApA>p Formation Terminating RNase Activity.