Literature DB >> 2808260

Does methylphenidate constrict cognitive functioning?

M V Solanto, E H Wender.   

Abstract

It has been suggested that stimulants enhance attention in children with (attention deficit disorder with hyperactivity) (ADDH) by producing a generalized constriction or "over-focusing." Such a phenomenon might be expected to adversely affect performance on tasks, such as those in the Wallach-Kogan (W-K) battery, which explicitly call for cognitive flexibility or "divergent thinking." Nineteen ADDH children, 6 to 10 years of age, were tested on two modified subtests of the W-K battery at baseline, following placebo, and following three different dosages (.3, .6 and 1.0 mg/kg) of methylphenidate. Contrary to the hypothesis, methylphenidate did not decrease but rather sustained output on the tests, which contrasted with a decline in productivity seen across nondrug days. Some ADDH subjects displayed particularly large increases in output following methylphenidate and may represent an atypical subgroup of children who became overaroused on medication.

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Year:  1989        PMID: 2808260     DOI: 10.1097/00004583-198911000-00014

Source DB:  PubMed          Journal:  J Am Acad Child Adolesc Psychiatry        ISSN: 0890-8567            Impact factor:   8.829


  13 in total

Review 1.  Pharmacokinetics and clinical effectiveness of methylphenidate.

Authors:  H C Kimko; J T Cross; D R Abernethy
Journal:  Clin Pharmacokinet       Date:  1999-12       Impact factor: 6.447

2.  Characterizing Creative Thinking and Creative Achievements in Relation to Symptoms of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Authors:  Marije Stolte; Victoria Trindade-Pons; Priscilla Vlaming; Babette Jakobi; Barbara Franke; Evelyn H Kroesbergen; Matthijs Baas; Martine Hoogman
Journal:  Front Psychiatry       Date:  2022-07-01       Impact factor: 5.435

3.  Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children.

Authors:  R Tannock; R Schachar; G Logan
Journal:  J Abnorm Child Psychol       Date:  1995-04

Review 4.  Adverse effects of pharmacotherapies for attention-deficit hyperactivity disorder: epidemiology, prevention and management.

Authors:  Johnny Graham; David Coghill
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

5.  Motor timing deficits in community and clinical boys with hyperactive behavior: the effect of methylphenidate on motor timing.

Authors:  Katya Rubia; Janet Noorloos; Anna Smith; Boudewijn Gunning; Joseph Sergeant
Journal:  J Abnorm Child Psychol       Date:  2003-06

6.  When we enhance cognition with Adderall, do we sacrifice creativity? A preliminary study.

Authors:  Martha J Farah; Caroline Haimm; Geena Sankoorikal; M Elizabeth Smith; Anjan Chatterjee
Journal:  Psychopharmacology (Berl)       Date:  2008-11-15       Impact factor: 4.530

7.  Effects of stimulant medication on divergent and convergent thinking tasks related to creativity in adults with attention-deficit hyperactivity disorder.

Authors:  Molly McBride; Carrina Appling; Bradley Ferguson; Alyssia Gonzalez; Andrea Schaeffer; Amanda Zand; David Wang; Alinna Sam; Eric Hart; Aneesh Tosh; Ivan Fontcha; Sophia Parmacek; David Beversdorf
Journal:  Psychopharmacology (Berl)       Date:  2021-09-03       Impact factor: 4.530

8.  Methylphenidate affects task-switching and neural signaling in non-human primates.

Authors:  Abigail Z Rajala; Luis C Populin; Rick L Jenison
Journal:  Psychopharmacology (Berl)       Date:  2020-02-18       Impact factor: 4.530

Review 9.  Methylphenidate for attention problems in epilepsy patients: Safety and efficacy.

Authors:  Beth A Leeman-Markowski; Jesse Adams; Samantha P Martin; Orrin Devinsky; Kimford J Meador
Journal:  Epilepsy Behav       Date:  2020-12-24       Impact factor: 2.937

Review 10.  Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies.

Authors:  Ole Jakob Storebø; Nadia Pedersen; Erica Ramstad; Maja Lærke Kielsholm; Signe Sofie Nielsen; Helle B Krogh; Carlos R Moreira-Maia; Frederik L Magnusson; Mathilde Holmskov; Trine Gerner; Maria Skoog; Susanne Rosendal; Camilla Groth; Donna Gillies; Kirsten Buch Rasmussen; Dorothy Gauci; Morris Zwi; Richard Kirubakaran; Sasja J Håkonsen; Lise Aagaard; Erik Simonsen; Christian Gluud
Journal:  Cochrane Database Syst Rev       Date:  2018-05-09
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