Ji Hye Huh1, Dhananjay Yadav2, Jae Seok Kim3, Jung-Woo Son4, Eunhee Choi5, Seong Hwan Kim6, Chol Shin6, Ki-Chul Sung7, Jang Young Kim8. 1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea. 2. Department of Preventive Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea. 3. Division of Nephrology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea. 4. Division of Cardiology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea. 5. Institute of Life Style Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea,. Electronic address: eunhee_choi@yonsei.ac.kr. 6. Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Gyeonggi, South Korea. 7. Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 8. Division of Cardiology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea,. Electronic address: kimjang713@gmail.com.
Abstract
OBJECTIVE: Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. MATERIAL AND METHODS: Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan-Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR <60ml/min per 1.73m2, and rapid decline of eGFR was defined as >3ml/min per 1.73m2/yr over 10years. RESULTS: During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16-1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04-1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04-1.47). CONCLUSION: Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.
OBJECTIVE: Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. MATERIAL AND METHODS: Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan-Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR <60ml/min per 1.73m2, and rapid decline of eGFR was defined as >3ml/min per 1.73m2/yr over 10years. RESULTS: During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16-1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04-1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04-1.47). CONCLUSION: Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.
Authors: María M Adeva-Andany; Carlos Fernández-Fernández; Lucía Adeva-Contreras; Natalia Carneiro-Freire; Alberto Domínguez-Montero; David Mouriño-Bayolo Journal: Curr Cardiol Rev Date: 2021
Authors: Hyeok Chan Kwon; Jun Yong Park; Sang-Won Lee; Soo Bin Lee; Mi Il Kang; Yong-Beom Park Journal: Rheumatol Int Date: 2021-06-04 Impact factor: 2.631