Gunveen Singh1, Tim Hodgson2, David E Clarke3. 1. Medical Student in Internal Medicine at the University of Otago School of Medicine in Dunedin, New Zealand. singu331@student.otago.ac.nz. 2. Pathology Registrar at the University of Otago School of Medicine in Dunedin, New Zealand. tim.hodgson@sclabs.co.nz. 3. Consultant in Medicine at The Dunedin Hospital; an Honorary Clinical Senior Lecturer at the University of Otago School of Medicine in Dunedin, New Zealand; Clinical Assistant Professor of Medicine at Stanford University School of Medicine; and a Hospitalist at the Santa Clara Medical Center in CA. davidclarkemd@mac.com.
Abstract
INTRODUCTION: Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis. CASE PRESENTATION: A 91-year-old man was diagnosed with ocular myasthenia gravis. He was started on pyridostigmine, and 2 weeks later he developed a rash. The rash was biopsied and found to be secondary to leukocytoclastic vasculitis; the pyridostigmine was stopped, loratadine was started, and the rash resolved. DISCUSSION: Leukocytoclastic vasculitis is commonly caused by a hypersensitivity reaction to medications, or it can be associated with certain medical conditions. We present a brief review of the most common medications and medical conditions known to cause this reaction, but to our knowledge this is the first description of pyridostigmine causing this reaction.
INTRODUCTION:Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis. CASE PRESENTATION: A 91-year-old man was diagnosed with ocular myasthenia gravis. He was started on pyridostigmine, and 2 weeks later he developed a rash. The rash was biopsied and found to be secondary to leukocytoclastic vasculitis; the pyridostigmine was stopped, loratadine was started, and the rash resolved. DISCUSSION: Leukocytoclastic vasculitis is commonly caused by a hypersensitivity reaction to medications, or it can be associated with certain medical conditions. We present a brief review of the most common medications and medical conditions known to cause this reaction, but to our knowledge this is the first description of pyridostigmine causing this reaction.
Authors: Cumali Karatoprak; Elif Arabaci; Kemal Yildiz; Mustafa Cakirca; Mehmet Ali Cikrikcioglu; Fatih Ergun; Ahmet Danalioglu; Orhan Kocaman; Hakan Senturk Journal: Case Rep Med Date: 2013-10-22
Authors: C A Barboza; A R Fukushima; N Carrozzi; J F Machi; P M M Dourado; C T Mostarda; M C Irigoyen; L Nathanson; M Morris; E C Caperuto; B Rodrigues Journal: Sci Rep Date: 2019-02-21 Impact factor: 4.379