Literature DB >> 28078773

Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts.

Haiyan Fu1, Peng-Xiang Shen1, Jian He1, Fanglin Zhang1, Suhua Li1, Peng Wang1, Tao Liu1, Jin-Quan Yu1.   

Abstract

The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp3 )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp3 )-H bonds of various carbocyclic rings were also successfully alkynylated.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  C−H activation; alkynylation; amino acids; palladium; pyridine

Mesh：

Substances：

Year:  2017        PMID： 28078773      PMCID： PMC5512278          DOI： 10.1002/anie.201610426

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  39 in total

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8.  Nickel-catalyzed arylation, alkenylation, and alkynylation of unprotected thioglycosides at room temperature.

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9.  Ligand-enabled triple C-H activation reactions: one-pot synthesis of diverse 4-aryl-2-quinolinones from propionamides.

Authors:  Youqian Deng; Wei Gong; Jian He; Jin-Quan Yu
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-14       Impact factor: 15.336

10.  Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds.

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Journal:  J Am Chem Soc       Date:  2014-09-15       Impact factor: 15.419
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  3 in total

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Authors:  Bin Liu; Andrew M Romine; Camille Z Rubel; Keary M Engle; Bing-Feng Shi
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2.  Palladium-Catalyzed Enantioselective β-C(sp3)-H Activation Reactions of Aliphatic Acids: A Retrosynthetic Surrogate for Enolate Alkylation and Conjugate Addition.

Authors:  Erika L Lucas; Nelson Y S Lam; Zhe Zhuang; Hau Sun Sam Chan; Daniel A Strassfeld; Jin-Quan Yu
Journal:  Acc Chem Res       Date:  2022-01-25       Impact factor: 24.466

3.  Synthesis of [13C₃]-B6 Vitamers Labelled at Three Consecutive Positions Starting from [13C₃]-Propionic Acid.

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  3 in total

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