Literature DB >> 2807378

Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits.

H Carlsten1, R Holmdahl, A Tarkowski, L A Nilsson.   

Abstract

The influence of sex steroids on cutaneous delayed-type hypersensitivity (DTH) and antibody responses to oxazolone (OXA) in autoimmune and normal mouse strains has been investigated. The results show that: (i) treatment with 17 beta-oestradiol (E2) suppresses DTH responses and stimulates antibody responses in MRL, B6 and C3H mice, suppresses DTH in DBA/1 mice, while having no effects on DTH or antibody responses in BALB/c and NFR/N mice. (ii) Treatment with testosterone suppresses the antibody response in all studied strains (MRL, B6, BALB/c and DBA/1) while down-regulating the DTH response only in MRL and B6 but not in BALB/c or DBA/1. (iii) Neither the lympho-proliferative (lpr) gene, which accelerates autoimmune disease, nor the H-2 genes seem to be directly related to the effects of sex hormones on the immune system. (iv) Susceptibility to oestrogen- and testosterone-mediated suppression of DTH but not oestrogen-mediated enhancement of antibody response are inherited as dominant traits. The results are discussed in the context of certain autoimmune diseases known to be influenced by sex hormone manipulations.

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Year:  1989        PMID： 2807378      PMCID： PMC1385419     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  18 in total

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Journal:  JAMA       Date:  1963-03-16       Impact factor: 56.272

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Journal:  Acta Endocrinol (Copenh)       Date:  1972-12

Review 3.  Etiopathogenesis of murine SLE.

Authors:  A N Theofilopoulos; F J Dixon
Journal:  Immunol Rev       Date:  1981       Impact factor: 12.988

4.  Approach to the study of the role of sex hormones in autoimmunity.

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Journal:  Arthritis Rheum       Date:  1979-11

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Authors:  D L Greenman; K Dooley; C R Breeden
Journal:  J Toxicol Environ Health       Date:  1977-10

6.  Oral contraceptives and rheumatoid arthritis: further evidence for a preventive effect.

Authors:  J P Vandenbroucke; H A Valkenburg; J W Boersma; A Cats; J J Festen; O Huber-Bruning; J J Rasker
Journal:  Lancet       Date:  1982-10-16       Impact factor: 79.321

7.  The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains.

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Journal:  Clin Immunol Immunopathol       Date:  1984-04

8.  Alterations of estrogen metabolism in systemic lupus erythematosus.

Authors:  R G Lahita; H L Bradlow; H G Kunkel; J Fishman
Journal:  Arthritis Rheum       Date:  1979-11

9.  Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.

Authors:  J R Roubinian; N Talal; J S Greenspan; J R Goodman; P K Siiteri
Journal:  J Exp Med       Date:  1978-06-01       Impact factor: 14.307

10.  Inheritance of antibody specificity V. Anti-2-phenyloxazolone in the mouse.

Authors:  O Näkelä; M Kaartinen; J L Pelkonen; K Karjalainen
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307
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  19 in total

1.  Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus.

Authors:  M C Erlandsson; C Ohlsson; J A Gustafsson; H Carlsten
Journal:  Immunology       Date:  2001-05       Impact factor: 7.397

2.  Analysis of the genetic encoding of oestradiol suppression of delayed-type hypersensitivity in (NZB x NZW) F1 mice.

Authors:  H Carlsten; R Holmdahl; A Tarkowski
Journal:  Immunology       Date:  1991-06       Impact factor: 7.397

3.  The sex ratios of probands and of secondary cases in conditions of multifactorial inheritance where liability varies with sex.

Authors:  W H James
Journal:  J Med Genet       Date:  1991-01       Impact factor: 6.318

4.  Estren-mediated inhibition of T lymphopoiesis is estrogen receptor-independent whereas its suppression of T cell-mediated inflammation is estrogen receptor-dependent.

Authors:  U Islander; M C Erlandsson; T Chavoshi; C Jochems; S Movérare; S Nilsson; C Ohlsson; J-A Gustafsson; H Carlsten
Journal:  Clin Exp Immunol       Date:  2005-02       Impact factor: 4.330

5.  T lymphocytes are not the target for estradiol-mediated suppression of DTH in reconstituted female severe combined immunodeficient (SCID) mice.

Authors:  M Taube; L Svensson; H Carlsten
Journal:  Clin Exp Immunol       Date:  1998-11       Impact factor: 4.330

6.  Relationship between onset of puberty and establishment of persistent infection with equine arteritis virus in the experimentally infected colt.

Authors:  G R Holyoak; T V Little; W H McCollam; P J Timoney
Journal:  J Comp Pathol       Date:  1993-07       Impact factor: 1.311

7.  Additive effects of suboptimal doses of estrogen and cortisone on the suppression of T lymphocyte dependent inflammatory responses in mice.

Authors:  H Carlsten; M Verdrengh; M Taube
Journal:  Inflamm Res       Date:  1996-01       Impact factor: 4.575

Review 8.  The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management.

Authors:  Ebru Karpuzoglu; Moncef Zouali
Journal:  Clin Rev Allergy Immunol       Date:  2011-02       Impact factor: 8.667

9.  17β-Estradiol protects against the progression of hypertension during adulthood in a mouse model of systemic lupus erythematosus.

Authors:  Emily L Gilbert; Keisa W Mathis; Michael J Ryan
Journal:  Hypertension       Date:  2013-12-23       Impact factor: 10.190

10.  Influence of oestrogen receptor alpha and beta on the immune system in aged female mice.

Authors:  U Islander; M C Erlandsson; B Hasséus; C A Jonsson; C Ohlsson; J-A Gustafsson; U Dahlgren; H Carlsten
Journal:  Immunology       Date:  2003-09       Impact factor: 7.397
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