| Literature DB >> 508372 |
R G Lahita, H L Bradlow, H G Kunkel, J Fishman.
Abstract
Estradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal controls was studied by measurement of urinary metabolites after injection of labeled 3H-estradiol. Patients with SLE manifested increased 16-hydroxylation of estrone. Diseases men differed from diseases women to the extent that only 16 alpha-hydroxyestrone was elevated in men, whereas women had elevations of both 16 alpha-hydroxyestrone and estriol. These data suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to increased estrogenic activity.Entities:
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Year: 1979 PMID： 508372 DOI： 10.1002/art.1780221106
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591