Literature DB >> 28073021

DNA Replication Checkpoint: New ATR Activator Identified.

Lee Zou1.   

Abstract

The ATR kinase is a master regulator of replication stress responses. Four new studies show that the protein ETAA1 is an important activator of ATR in human cells, providing insights into how the ATR pathway reacts to replication stress.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28073021     DOI： 10.1016/j.cub.2016.11.025

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  7 in total

1.  RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Authors:  Huzefa Dungrawala; Kamakoti P Bhat; Rémy Le Meur; Walter J Chazin; Xia Ding; Shyam K Sharan; Sarah R Wessel; Aditya A Sathe; Runxiang Zhao; David Cortez
Journal:  Mol Cell       Date:  2017-07-20       Impact factor: 17.970

2.  SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

Authors:  Swagata Halder; Ignacio Torrecilla; Martin D Burkhalter; Marta Popović; John Fielden; Bruno Vaz; Judith Oehler; Domenic Pilger; Davor Lessel; Katherine Wiseman; Abhay Narayan Singh; Iolanda Vendrell; Roman Fischer; Melanie Philipp; Kristijan Ramadan
Journal:  Nat Commun       Date:  2019-07-17       Impact factor: 14.919

3.  Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.

Authors:  Jian-Fang Ning; Monica Stanciu; Melissa R Humphrey; Joshua Gorham; Hiroko Wakimoto; Reiko Nishihara; Jacqueline Lees; Lee Zou; Robert L Martuza; Hiroaki Wakimoto; Samuel D Rabkin
Journal:  Nat Commun       Date:  2019-07-02       Impact factor: 14.919

4.  Treacle and TOPBP1 control replication stress response in the nucleolus.

Authors:  Artem K Velichko; Natalia Ovsyannikova; Nadezhda V Petrova; Artem V Luzhin; Maria Vorobjeva; Alexey S Gavrikov; Alexander S Mishin; Igor I Kireev; Sergey V Razin; Omar L Kantidze
Journal:  J Cell Biol       Date:  2021-06-08       Impact factor: 10.539

5.  A consensus set of genetic vulnerabilities to ATR inhibition.

Authors:  Nicole Hustedt; Alejandro Álvarez-Quilón; Andrea McEwan; Jing Yi Yuan; Tiffany Cho; Lisa Koob; Traver Hart; Daniel Durocher
Journal:  Open Biol       Date:  2019-09-11       Impact factor: 6.411

6.  Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.

Authors:  Jennifer Ann Black; Kathryn Crouch; Leandro Lemgruber; Craig Lapsley; Nicholas Dickens; Luiz R O Tosi; Jeremy C Mottram; Richard McCulloch
Journal:  Cell Rep       Date:  2020-01-21       Impact factor: 9.423

7.  A model of DNA damage response activation at stalled replication forks by SPRTN.

Authors:  Christopher Bruhn; Marco Foiani
Journal:  Nat Commun       Date:  2019-12-12       Impact factor: 14.919
  7 in total

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