Literature DB >> 280718

Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.

B Toth.   

Abstract

A solution of 0.125% 1-hydrazinophthalazine hydrochloride, an antihypertensive drug widely used in humans, was given continuously in drinking water for the life-spans of randomly bred Swiss mice. Consumption of the chemical significantly increased the lung tumor incidence from 36 to 60% in females and from 26 to 46% in males, compared to controls. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs.

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Year:  1978        PMID： 280718     DOI： 10.1093/jnci/61.5.1363

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  6 in total

1.  Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes.

Authors:  C A McQueen; C J Maslansky; I B Glowinski; S B Crescenzi; W W Weber; G M Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

2.  Actual new cancer-causing hydrazines, hydrazides, and hydrazones.

Authors:  B Toth
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

3.  BIOTRANSFORMATION OF HYDRAZINE DERVATIVES IN THE MECHANISM OF TOXICITY.

Authors:  Birandra K Sinha; Ronald P Mason
Journal:  J Drug Metab Toxicol       Date:  2014-07-08

4.  DNA cleavage and detection of DNA radicals formed from hydralazine and copper (II) by ESR and immuno-spin trapping.

Authors:  Birandra K Sinha; Fabian Leinisch; Suchandra Bhattacharjee; Ronald P Mason
Journal:  Chem Res Toxicol       Date:  2014-02-13       Impact factor: 3.739

5.  A pilot study on risk factors and p53 gene expression in colorectal cancer.

Authors:  M Fredrikson; O Axelson; X F Sun; G Arbman; E Nilsson; B Nordenskjöld; R Sjödahl; P Söderkvist
Journal:  Br J Cancer       Date:  1996-06       Impact factor: 7.640

6.  Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.

Authors:  H Mori; S Sugie; N Yoshimi; H Iwata; A Nishikawa; K Matsukubo; H Shimizu; I Hirono
Journal:  Jpn J Cancer Res       Date:  1988-02
  6 in total

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