| Literature DB >> 28068767 |
Abhay U Andar1, Ram Karan2, Wolf T Pecher2,3, Priya DasSarma2, William D Hedrich1, Audra L Stinchcomb1, Shiladitya DasSarma2.
Abstract
Gas vesicle nanoparticles (GVNPs) are hollow, buoyant protein organelles produced by the extremophilic microbe Halobacterium sp. NRC-1 and are being developed as bioengineerable and biocompatible antigen and drug-delivery systems (DDS). Dynamic light scattering measurements of purified GVNP suspensions showed a mean diameter of 245 nm. In vitro diffusion studies using Yucatan miniature pig skin showed GVNP permeation to be enhanced after MN-treatment compared to untreated skin. GVNPs were found to be nontoxic to mammalian cells (human kidney and rat mycocardial myoblasts). These findings support the use of GVNPs as DDS for intradermal/transdermal permeation of protein- and peptide-based drugs.Entities:
Keywords: Yucatan minipig skin; gas vesicle nanoparticles; halobacterium; in vitro; microneedles
Mesh：
Substances：
Year: 2017 PMID： 28068767 DOI： 10.1021/acs.molpharmaceut.6b00859
Source DB: PubMed Journal: Mol Pharm ISSN： 1543-8384 Impact factor: 4.939