Literature DB >> 2806605

The effects of platelet-activating factor on the motility of human spermatozoa.

D D Ricker1, B S Minhas, R Kumar, J L Robertson, M G Dodson.   

Abstract

Our laboratory has recently detected the presence of platelet-activating factor (PAF)-like activity in human spermatozoa. To gain further insight into the role of PAF on the male reproductive system, this study, using videomicroscopy, evaluated the effects of synthetic PAF on the motility of human spermatozoa. Treatment of 20 human semen samples with 3.69 x 10(-7) to 3.69 x 10(-13) M PAF resulted in statistically significant increases in motility. Treatment of spermatozoa with lyso-PAF (the biologically inactive form of PAF) showed no change in motility. Treatment of spermatozoa with PAF in severely asthenozoospermic males may be of therapeutic value.

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Year:  1989        PMID： 2806605     DOI： 10.1016/s0015-0282(16)60981-0

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  12 in total

1.  Follicular fluid enhances sperm attraction and its motility in human.

Authors:  B G Jeon; J S Moon; K C Kim; H J Lee; S Y Choe; G J Rho
Journal:  J Assist Reprod Genet       Date:  2001-08       Impact factor: 3.412

Review 2.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

3.  Platelet activating factor treatment of spermatozoa enhances rabbit oocyte fertilization following subzonal sperm insertion.

Authors:  B S Minhas; H N Kim; Y P Zhu; B A Ripps; T H Burwinkel
Journal:  J Assist Reprod Genet       Date:  1994-07       Impact factor: 3.412

4.  Embryonic platelet activating factor production in the rabbit increases during the preimplantation phase.

Authors:  B S Minhas; Y P Zhu; H N Kim; T H Burwinkel; B A Ripps; J E Buster
Journal:  J Assist Reprod Genet       Date:  1993-07       Impact factor: 3.412

5.  Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase.

Authors:  S Soubeyrand; C Lazure; P Manjunath
Journal:  Biochem J       Date:  1998-01-01       Impact factor: 3.857

6.  Exogenous platelet-activating factor improves the motility of human spermatozoa evaluated with C.A.S.A.: optimal concentration and incubation time.

Authors:  G Grassi; N Cappello; M F Gheorghe; L Salton; C Di Bisceglie; C Manieri; C Benedetto
Journal:  J Endocrinol Invest       Date:  2010-03-10       Impact factor: 4.256

7.  Enhanced embryo development of rabbit oocytes fertilized in vitro with platelet activating factor (PAF)-treated spermatozoa.

Authors:  W E Roudebush; A I Fukuda; B S Minhas
Journal:  J Assist Reprod Genet       Date:  1993-01       Impact factor: 3.412

8.  The effect of platelet activating factor on different phases of murine in vitro fertilization.

Authors:  H Shi; F Miller; K Miller; M H Kim
Journal:  J Assist Reprod Genet       Date:  1992-08       Impact factor: 3.412

9.  Effect of PAF on erythrocyte membrane heterogeneity: a fluorescence study.

Authors:  A Kantar; P L Giorgi; G Curatola; R Fiorini
Journal:  Agents Actions       Date:  1991-03

10.  Effects of platelet activating factor on mouse sperm function.

Authors:  K Sengoku; M Ishikawa; K Tamate; T Shimizu
Journal:  J Assist Reprod Genet       Date:  1992-10       Impact factor: 3.412
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