| Literature DB >> 2806380 |
I A Deckers1, M Rampart, H Bult, A G Herman.
Abstract
A sensitive high pressure liquid chromatography (HPLC) method was used to measure acetylcholine release from canine bronchial tissue in response to electrical stimulation. Indomethacin enhanced the efflux of acetylcholine, an effect that was reversed by the addition of prostaglandin E2 (PGE2). Prostaglandin D2 (PGD2) had no effect on acetylcholine output. These data suggest that prostaglandins, possibly PGE2, are involved in a negative feedback control mechanism for acetylcholine release in canine bronchi.Entities:
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Year: 1989 PMID: 2806380 DOI: 10.1016/0014-2999(89)90451-2
Source DB: PubMed Journal: Eur J Pharmacol ISSN: 0014-2999 Impact factor: 4.432