Beibei Zhang1, Weiming Zhang2, Liang Yan3, Daogang Wang4. 1. Department of Molecular Microbiology, Oslo University Hospital, Oslo, Norway. 2. Department of Oncology, The Affiliated Hospital of Binzhou Medical College, Binzhou, PR China. 3. Department of Oncology, Binzhou People's Hospital, Binzhou, PR China. 4. Department of Gastroenterology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, PR China. Electronic address: gxcmuwdg@126.com.
Abstract
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is closely related to the acute lymphoblastic leukaemia (ALL) indicated by many previous epidemiologic studies. However, their conclusions were still conflicting. METHODS: Our aim is to evaluate their associations using a more comprehensive updated meta-analysis. Electronic searches were conducted to select published studies prior to February, 2016. RESULTS: Totally, 39 case-control studies including 6551 ALL cases and 10,918 controls were selected in current meta-analysis. The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility. CONCLUSIONS: Our results indicate that the MTHFR C677T polymorphism may be a promising ALL biomarker and studies to explore the protein levels of the variants and their functional role are required for the definitive conclusions.
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is closely related to the acute lymphoblastic leukaemia (ALL) indicated by many previous epidemiologic studies. However, their conclusions were still conflicting. METHODS: Our aim is to evaluate their associations using a more comprehensive updated meta-analysis. Electronic searches were conducted to select published studies prior to February, 2016. RESULTS: Totally, 39 case-control studies including 6551 ALL cases and 10,918 controls were selected in current meta-analysis. The association was detected significantly between MTHFRC677T polymorphism and ALL reducing susceptibility. CONCLUSIONS: Our results indicate that the MTHFRC677T polymorphism may be a promising ALL biomarker and studies to explore the protein levels of the variants and their functional role are required for the definitive conclusions.