Literature DB >> 28059778

Rational design of vaccine targets and strategies for HIV: a crossroad of statistical physics, biology, and medicine.

Arup K Chakraborty1, John P Barton.   

Abstract

Vaccination has saved more lives than any other medical procedure. Pathogens have now evolved that have not succumbed to vaccination using the empirical paradigms pioneered by Pasteur and Jenner. Vaccine design strategies that are based on a mechanistic understanding of the pertinent immunology and virology are required to confront and eliminate these scourges. In this perspective, we describe just a few examples of work aimed to achieve this goal by bringing together approaches from statistical physics with biology and clinical research.

Mesh：

Substances：

Year:  2017        PMID： 28059778     DOI： 10.1088/1361-6633/aa574a

Source DB:  PubMed          Journal:  Rep Prog Phys        ISSN： 0034-4885


  7 in total

1.  Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.

Authors:  Dariusz K Murakowski; John P Barton; Lauren Peter; Abishek Chandrashekar; Esther Bondzie; Ang Gao; Dan H Barouch; Arup K Chakraborty
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-02       Impact factor: 11.205

2.  Modelling and in vitro testing of the HIV-1 Nef fitness landscape.

Authors:  John P Barton; Erasha Rajkoomar; Jaclyn K Mann; Dariusz K Murakowski; Mako Toyoda; Macdonald Mahiti; Phillip Mwimanzi; Takamasa Ueno; Arup K Chakraborty; Thumbi Ndung'u
Journal:  Virus Evol       Date:  2019-08-05

3.  Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.

Authors:  Syed Faraz Ahmed; Ahmed A Quadeer; Matthew R McKay
Journal:  Viruses       Date:  2020-02-25       Impact factor: 5.048

4.  Epistatic contributions promote the unification of incompatible models of neutral molecular evolution.

Authors:  Jose Alberto de la Paz; Charisse M Nartey; Monisha Yuvaraj; Faruck Morcos
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-02       Impact factor: 11.205

Review 5.  In silico T cell epitope identification for SARS-CoV-2: Progress and perspectives.

Authors:  Muhammad Saqib Sohail; Syed Faraz Ahmed; Ahmed Abdul Quadeer; Matthew R McKay
Journal:  Adv Drug Deliv Rev       Date:  2021-01-17       Impact factor: 17.873

6.  Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape.

Authors:  Ahmed A Quadeer; John P Barton; Arup K Chakraborty; Matthew R McKay
Journal:  Nat Commun       Date:  2020-01-17       Impact factor: 14.919

7.  Development of antibacterial compounds that constrain evolutionary pathways to resistance.

Authors:  Yanmin Zhang; Sourav Chowdhury; João V Rodrigues; Eugene Shakhnovich
Journal:  Elife       Date:  2021-07-19       Impact factor: 8.140
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.