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Literature DB >> 28054745

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis".

Abstract

The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.

Entities: Disease

Keywords: zzm321990APPzzm321990; Alzheimer's disease; Down syndrome; amyloid; genetics

Mesh：

Substances：

Year: 2017 PMID： 28054745 DOI： 10.1111/febs.14004

Source DB: PubMed Journal: FEBS J ISSN： 1742-464X Impact factor: 5.542

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Cited

46 in total

1. Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?

Authors: Polyxeni Stamati; Vasileios Siokas; Athina-Maria Aloizou; Emmanouil Karampinis; Stylianos Arseniou; Valerii N Rakitskii; Aristidis Tsatsakis; Demetrios A Spandidos; Illana Gozes; Panayiotis D Mitsias; Dimitrios P Bogdanos; Georgios M Hadjigeorgiou; Efthimios Dardiotis
Journal: J Mol Neurosci Date: 2019-07-02 Impact factor: 3.444

2. Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway.

Authors: Xiao-Long Wu; Ying Chen; Wen-Cui Kong; Zhong-Quan Zhao
Journal: J Zhejiang Univ Sci B Date: 2020 Mar. Impact factor: 3.066

Review 3. Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.

Authors: Chinthalapally V Rao; Mudassir Farooqui; Adam S Asch; Hiroshi Y Yamada
Journal: Cell Cycle Date: 2018-09-20 Impact factor: 4.534

4. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Authors: Panos Theofilas; Alexander J Ehrenberg; Austin Nguy; Julia M Thackrey; Sara Dunlop; Maria B Mejia; Ana T Alho; Renata Elaine Paraizo Leite; Roberta Diehl Rodriguez; Claudia K Suemoto; Camila F Nascimento; Marcus Chin; Daniel Medina-Cleghorn; Ana Maria Cuervo; Michelle Arkin; William W Seeley; Bruce L Miller; Ricardo Nitrini; Carlos Augusto Pasqualucci; Wilson Jacob Filho; Udo Rueb; John Neuhaus; Helmut Heinsen; Lea T Grinberg
Journal: Neurobiol Aging Date: 2017-09-20 Impact factor: 4.673

Review 5. The emerging link between O-GlcNAcylation and neurological disorders.

Authors: Xiaofeng Ma; He Li; Yating He; Junwei Hao
Journal: Cell Mol Life Sci Date: 2017-05-22 Impact factor: 9.261

6. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.

Authors: Viviana Soto-Mercado; Miguel Mendivil-Perez; Carlos Velez-Pardo; Francisco Lopera; Marlene Jimenez-Del-Rio
Journal: PLoS One Date: 2020-05-21 Impact factor: 3.240

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis".

1. Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?

2. Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway.

Review 3. Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.

4. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans.

Review 5. The emerging link between O-GlcNAcylation and neurological disorders.

6. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.

Review 7. Does traumatic brain injury hold the key to the Alzheimer's disease puzzle?

Review 8. Dementia in Down syndrome: unique insights for Alzheimer disease research.

Review 9. Cognitive Impairment in Older Adults and Therapeutic Strategies.

Review 10. Genetic Insights into Alzheimer's Disease.