May Lynn Quan1,2, Lawrence Frank Paszat2,3,4, Kimberly A Fernandes2, Rinku Sutradhar2,4, David R McCready5,6, Eileen Rakovitch2,3, Ellen Warner3, Frances C Wright3,4,6, Nicole Hodgson7, Muriel Brackstone8, Nancy N Baxter2,4,6,9. 1. Foothills Medical Centre, University of Calgary, Calgary, Canada. 2. Institute for Clinical Evaluative Sciences, Toronto, Canada. 3. Sunnybrook Health Sciences Centre, Toronto, Canada. 4. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada. 5. University Health Network-Princess Margaret Hospital, Toronto, Canada. 6. Department of Surgery, University of Toronto, Toronto, Canada. 7. Juravinski Cancer Centre, Hamilton, Canada. 8. London Health Sciences Centre, Victoria Hospital, London, Canada. 9. Department of Surgery, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
Abstract
BACKGROUND: The impact of surgical treatment on outcomes in breast cacner in very young women remains unclear. We sought to determine the effect of surgery type on risk of recurrence and survival in a population-based cohort. METHODS: All women diagnosed with breast cancer aged ≤35 (1994-2003) were identified from the Ontario Cancer Registry. Patient, tumor, and treatment variables, including primary surgery, recurrences, and death were abstracted from chart review. Cox regression models were fit to determine the effect of surgery type on recurrence and overall survival. RESULTS: We identified 1,381 patients with 11-year median follow-up of which 793 (57%) had BCS. Of the remaining mastectomy patients, 52% had postmastectomy radiation. Overall, 41% of patients sustained a recurrence of any type and 31% died. Controlling for known confounders, there was no association between type of surgery and death from any cause (HR = 0.98, 95% CI = 0.78, 1.25) or first recurrence (HR = 0.93, 95% CI = 0.75, 1.14). Distant recurrence was most common (13% in BCS; 25.3% in mastectomy) with local recurrence 12.4% after BCS and 7.5% after mastectomy. CONCLUSIONS: In this cohort of very young women who were selected for treatment with BCS and mastectomy, we found similar oncologic outcomes. J. Surg. Oncol. 2017;115:122-130.
BACKGROUND: The impact of surgical treatment on outcomes in breast cacner in very young women remains unclear. We sought to determine the effect of surgery type on risk of recurrence and survival in a population-based cohort. METHODS: All women diagnosed with breast cancer aged ≤35 (1994-2003) were identified from the Ontario Cancer Registry. Patient, tumor, and treatment variables, including primary surgery, recurrences, and death were abstracted from chart review. Cox regression models were fit to determine the effect of surgery type on recurrence and overall survival. RESULTS: We identified 1,381 patients with 11-year median follow-up of which 793 (57%) had BCS. Of the remaining mastectomy patients, 52% had postmastectomy radiation. Overall, 41% of patients sustained a recurrence of any type and 31% died. Controlling for known confounders, there was no association between type of surgery and death from any cause (HR = 0.98, 95% CI = 0.78, 1.25) or first recurrence (HR = 0.93, 95% CI = 0.75, 1.14). Distant recurrence was most common (13% in BCS; 25.3% in mastectomy) with local recurrence 12.4% after BCS and 7.5% after mastectomy. CONCLUSIONS: In this cohort of very young women who were selected for treatment with BCS and mastectomy, we found similar oncologic outcomes. J. Surg. Oncol. 2017;115:122-130.
Authors: Hassan K Abdulwassi; Ibrahim T Amer; Ahmad H Alhibshi; Abdullah A Alnajjar; Abdulrahman K Bahatheq; Nora H Trabulsi; Mohammed O Nassif Journal: Saudi Med J Date: 2020-04 Impact factor: 1.484