Literature DB >> 28054112

[Surgical treatment of colorectal carcinoma in the elderly].

J Schuld1,2, M Glanemann3.   

Abstract

Colorectal carcinoma is one of the most frequent tumor entities worldwide. The treatment of elderly and mostly polymorbid patients is an outstanding challenge in view of the demographic change with a continuously aging community. Due to the demographic changes the numbers of elderly (>65 years) and very old (≥80 years) patients are steadily increasing in surgical cohorts. This has resulted in higher morbidity and mortality rates in comparison to younger patients, with increased wound healing and cardiovascular complications but with comparable numbers of anastomotic insufficiency. Multivariate analysis revealed age ≥80 years, higher ASA status and emergency operations as independent risk factors for increased in-hospital mortality. With respect to the localization of colorectal cancer a shift to the right has been observed with increasing patient age. Whether minimally invasive surgical techniques can reduce postoperative morbidity and mortality rates in elderly patients requires further evaluation. Nevertheless, a reduction of both was reported without compromising the oncological result. Elderly patients require individualized treatment modalities, which take the extent of comorbidities and personal environment into consideration. So far, the cohort of octogenarians has not been adequately considered in current guidelines; therefore, geriatric expertise is recommended to be able to make a better assessment of benefit-risk ratios, as age itself has no impact on the decision for therapy.

Entities:  

Keywords:  Comorbidities; Geriatrics; Infection; Risk; Surgery

Mesh:

Year:  2017        PMID: 28054112     DOI: 10.1007/s00104-016-0342-7

Source DB:  PubMed          Journal:  Chirurg        ISSN: 0009-4722            Impact factor:   0.955


  30 in total

Review 1.  Frailty in the older surgical patient: a review.

Authors:  Judith S L Partridge; Danielle Harari; Jugdeep K Dhesi
Journal:  Age Ageing       Date:  2012-03       Impact factor: 10.668

2.  The assessment and management of older cancer patients: A SIOG surgical task force survey on surgeons' attitudes.

Authors:  F Ghignone; B L van Leeuwen; I Montroni; M G Huisman; P Somasundar; K L Cheung; R A Audisio; G Ugolini
Journal:  Eur J Surg Oncol       Date:  2015-12-17       Impact factor: 4.424

3.  Colorectal cancer in the elderly and the influence of lead time bias: better survival does not equate with improved life expectancy.

Authors:  Katrina Knight; Raymond Oliphant; Fraser Maxwell; Claire McKenzie; Maria McCann; Raymond Hammill; Praveen Sharma; Angus Macdonald
Journal:  Int J Colorectal Dis       Date:  2016-01-19       Impact factor: 2.571

4.  Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.

Authors:  Rolf Sauer; Torsten Liersch; Susanne Merkel; Rainer Fietkau; Werner Hohenberger; Clemens Hess; Heinz Becker; Hans-Rudolf Raab; Marie-Therese Villanueva; Helmut Witzigmann; Christian Wittekind; Tim Beissbarth; Claus Rödel
Journal:  J Clin Oncol       Date:  2012-04-23       Impact factor: 44.544

5.  Rectal cancer surgery in patients more than 80 years of age.

Authors:  Alain Barrier; Leonardo Ferro; Sidney Houry; François Lacaine; Michel Huguier
Journal:  Am J Surg       Date:  2003-01       Impact factor: 2.565

6.  Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-β.

Authors:  Anja Rudolph; Csaba Toth; Michael Hoffmeister; Wilfried Roth; Esther Herpel; Peter Schirmacher; Hermann Brenner; Jenny Chang-Claude
Journal:  Cancer Res       Date:  2013-04-12       Impact factor: 12.701

Review 7.  Declining Bowel Cancer Incidence and Mortality in Germany.

Authors:  Hermann Brenner; Petra Schrotz-King; Bernd Holleczek; Alexander Katalinic; Michael Hoffmeister
Journal:  Dtsch Arztebl Int       Date:  2016-02-19       Impact factor: 5.594

Review 8.  Colorectal cancer.

Authors:  Hermann Brenner; Matthias Kloor; Christian Peter Pox
Journal:  Lancet       Date:  2013-11-11       Impact factor: 79.321

9.  Does chronic kidney disease affect outcomes after major abdominal surgery? Results from the National Surgical Quality Improvement Program.

Authors:  Jordan M Cloyd; Yifei Ma; John M Morton; Manjula Kurella Tamura; George A Poultsides; Brendan C Visser
Journal:  J Gastrointest Surg       Date:  2013-11-16       Impact factor: 3.452

10.  Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany.

Authors:  Ondrej Majek; Adam Gondos; Lina Jansen; Katharina Emrich; Bernd Holleczek; Alexander Katalinic; Alice Nennecke; Andrea Eberle; Hermann Brenner
Journal:  PLoS One       Date:  2013-07-05       Impact factor: 3.240

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  2 in total

Review 1.  The Perioperative Care of Older Patients.

Authors:  Cynthia Olotu; Arved Weimann; Christian Bahrs; Wolfgang Schwenk; Martin Scherer; Rainer Kiefmann
Journal:  Dtsch Arztebl Int       Date:  2019-02-01       Impact factor: 5.594

2.  Examination of Risk Factors for the Development of Surgical Site Infections.

Authors:  Slobodan Stanic; Janja Bojanic; Predrag Grubor; Biljana Mijovic; Veljko Maric
Journal:  Mater Sociomed       Date:  2017-06
  2 in total

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