Literature DB >> 28053381

A simple method for fashioning an antibiotic impregnated cemented rod for intramedullary placement in infected non-union of long bones.

Ajay Bharti1, Umesh Kumar Saroj2, Vineet Kumar3, Sanjay Kumar1, Balram Ji Omar4.   

Abstract

The intramedullary insertion of antibiotic impregnated PMMA rods, beads or nails are widely used and accepted modality of treatment for chronic osteomyelitis of long bones. But at times it becomes difficult to insert and remove these antibiotic delivery systems owing to narrowed medullary canals. Here we present a technique for preparing PMMA rods with diameter ranging from 6 mm to 3 mm. These rods could easily be placed in narrow intramedullary canal of long bones with chronic osteomyelitis or infected non-union. We have used high viscosity bone cement (Simplex P) along with two antibiotics (cefuroxime and vancomycin) for preparing cement rods. Food grade straw and low profile teflon tube guide wire exchanger used in IM nailing were used as mold. Ilizarov wire, 1 mm K wire and 24 gauge stainless steel wire were used as internal support core material for imparting strength. We used this technique in seven cases and were successful in treating infection of long bones of upper and lower limbs (femur). With average follow up of 7.28 months rate of union in our series was 71% (five cases). Four cases (57%) had no evidence of infection and two cases (29%) had control of infection and in one case (14%) infection was still there but union was achieved.

Entities:  

Keywords:  Antibiotic; Non-union; Osteomyelitis; PMMA; Rod

Year:  2016        PMID: 28053381      PMCID: PMC5197058          DOI: 10.1016/j.jcot.2016.08.004

Source DB:  PubMed          Journal:  J Clin Orthop Trauma        ISSN: 0976-5662


  17 in total

1.  The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone-cements: a pharmacokinetic study.

Authors:  Daniela Cerretani; Giorgio Giorgi; Paolo Fornara; Luigi Bocchi; Laura Neri; Remo Ceffa; Franco Ghisellini; Merrill A Ritter
Journal:  J Arthroplasty       Date:  2002-08       Impact factor: 4.757

Review 2.  Local antibiotic delivery vehicles in the treatment of musculoskeletal infection.

Authors:  Arlen D Hanssen
Journal:  Clin Orthop Relat Res       Date:  2005-08       Impact factor: 4.176

Review 3.  Antibiotic-loaded bone cement for infection prophylaxis in total joint replacement.

Authors:  William A Jiranek; Arlen D Hanssen; A Seth Greenwald
Journal:  J Bone Joint Surg Am       Date:  2006-11       Impact factor: 5.284

Review 4.  Infected nonunion of the long bones.

Authors:  Peter A A Struijs; Rudolf W Poolman; Mohit Bhandari
Journal:  J Orthop Trauma       Date:  2007-08       Impact factor: 2.512

5.  Biological and biomechanical effects of vancomycin and meropenem in acrylic bone cement.

Authors:  Massimiliano Baleani; Cecilia Persson; Carola Zolezzi; Agnese Andollina; Anna Maria Borrelli; Domenico Tigani
Journal:  J Arthroplasty       Date:  2008-04-14       Impact factor: 4.757

6.  Antibiotic cement-coated nails for the treatment of infected nonunions and segmental bone defects.

Authors:  Raghuram Thonse; Janet D Conway
Journal:  J Bone Joint Surg Am       Date:  2008-11       Impact factor: 5.284

7.  Intramedullary infections treated with antibiotic cement rods: preliminary results in nine cases.

Authors:  Dror Paley; John E Herzenberg
Journal:  J Orthop Trauma       Date:  2002 Nov-Dec       Impact factor: 2.512

8.  In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads.

Authors:  K Adams; L Couch; G Cierny; J Calhoun; J T Mader
Journal:  Clin Orthop Relat Res       Date:  1992-05       Impact factor: 4.176

9.  Use of antibiotic cement rod to treat intramedullary infection after nailing: preliminary study in 19 patients.

Authors:  Zheng Qiang; Pan Zhi Jun; Xu Jian Jie; Li Hang; Li Jian Bing; Li Fang Cai
Journal:  Arch Orthop Trauma Surg       Date:  2007-03-27       Impact factor: 3.067

10.  Use of antibiotic cement-impregnated intramedullary nail in treatment of infected non-union of long bones.

Authors:  Ashok K Shyam; Parag K Sancheti; Salim K Patel; Steve Rocha; Chetan Pradhan; Atul Patil
Journal:  Indian J Orthop       Date:  2009-10       Impact factor: 1.251

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  5 in total

1.  Treatment of Proximal Femur Osteomyelitis Occurred after Proximal Femoral Nail Antirotation Fixation, with Antibiotic Cement-coated Tibia Intramedullary Nail: A Case Report.

Authors:  Jong Ho Noh; Sung Jun Koh; Kee Haeng Lee
Journal:  Hip Pelvis       Date:  2018-03-05

2.  Postoperative Chronic Osteomyelitis in the Long Bones - Current Knowledge and Management of the Problem.

Authors:  Lourenço Galizia Heitzmann; Raphael Battisti; Ayres Fernando Rodrigues; Juliano Valente Lestingi; Cinthya Cavazzana; Roberto Dantas Queiroz
Journal:  Rev Bras Ortop (Sao Paulo)       Date:  2019-12-13

3.  Treatment of chronic osteomyelitis with antibiotic-impregnated polymethyl methacrylate (PMMA) - the Cierny approach: is the second stage necessary?

Authors:  Noam Bor; Eytan Dujovny; Barak Rinat; Nimrod Rozen; Guy Rubin
Journal:  BMC Musculoskelet Disord       Date:  2022-01-06       Impact factor: 2.362

Review 4.  Recent advances in the local antibiotics delivery systems for management of osteomyelitis.

Authors:  Reem Khaled Wassif; Maha Elkayal; Rehab Nabil Shamma; Seham A Elkheshen
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.819

5.  Antibiotic cement coating in orthopedic surgery: a systematic review of reported clinical techniques.

Authors:  Abdullah Ismat; Nike Walter; Susanne Baertl; Joerg Mika; Siegmund Lang; Maximilian Kerschbaum; Volker Alt; Markus Rupp
Journal:  J Orthop Traumatol       Date:  2021-12-23
  5 in total

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