Hodaka Yamada1, Makoto Kuro-O2, San-E Ishikawa3, Shunsuke Funazaki1, Ikuyo Kusaka1, Masafumi Kakei1, Kazuo Hara1. 1. Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, Saitama, Japan. 2. Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan. 3. Division of Endocrinology and Metabolism, International University of Health and Welfare Hospital, Tochigi, Japan.
Abstract
AIM: Calciprotein particles (CPPs), colloidal protein-mineral nanoparticles composed of solid-phase calcium phosphate and serum protein fetuin-A found in blood, are emerging as a novel component of chronic kidney disease-mineral and bone disorder (CKD-MBD). The relationship of CPPs with factors known to underlie the CKD-MBD pathophysiology is not well known.The aim of this study is to examine daily variations in CPPs as well as their association with mineral metabolism parameters in normal individuals and early-stage CKD patients. METHODS: Twenty subjects (10 healthy adults, 10 diabetic patients) were enrolled. Serum CPP Fetuin-A was measured and analyzed in relation to clinical parameters. RESULTS: Estimated glomerular filtration rates (eGFR) were 103 ± 11 and 75 ± 24 mL/min per 1.73 m2 in healthy adults and diabetic patients, respectively. Serum CPP Fetuin-A (g/L) were elevated at postprandial 2 h in diabetic patients. Furthermore, serum CPP Fetuin-A were inversely correlated with eGFR and serum 1,25-dihydroxyvitamin D3 and magnesium levels and were positively correlated with serum fibroblast growth factor-23. CONCLUSIONS: These findings indicated that serum CPP Fetuin-A were affected by food intake and may contribute to the pathophysiology of mineral metabolism in subjects with normal and moderately impaired renal function.
AIM: Calciprotein particles (CPPs), colloidal protein-mineral nanoparticles composed of solid-phase calcium phosphate and serum protein fetuin-A found in blood, are emerging as a novel component of chronic kidney disease-mineral and bone disorder (CKD-MBD). The relationship of CPPs with factors known to underlie the CKD-MBD pathophysiology is not well known.The aim of this study is to examine daily variations in CPPs as well as their association with mineral metabolism parameters in normal individuals and early-stage CKD patients. METHODS: Twenty subjects (10 healthy adults, 10 diabeticpatients) were enrolled. Serum CPP Fetuin-A was measured and analyzed in relation to clinical parameters. RESULTS: Estimated glomerular filtration rates (eGFR) were 103 ± 11 and 75 ± 24 mL/min per 1.73 m2 in healthy adults and diabeticpatients, respectively. Serum CPP Fetuin-A (g/L) were elevated at postprandial 2 h in diabeticpatients. Furthermore, serum CPP Fetuin-A were inversely correlated with eGFR and serum 1,25-dihydroxyvitamin D3 and magnesium levels and were positively correlated with serum fibroblast growth factor-23. CONCLUSIONS: These findings indicated that serum CPP Fetuin-A were affected by food intake and may contribute to the pathophysiology of mineral metabolism in subjects with normal and moderately impaired renal function.
Authors: Mark K Tiong; Michael M X Cai; Nigel D Toussaint; Sven-Jean Tan; Andreas Pasch; Edward R Smith Journal: Sci Rep Date: 2022-05-05 Impact factor: 4.996
Authors: Daria Shishkova; Elena Velikanova; Maxim Sinitsky; Anna Tsepokina; Olga Gruzdeva; Leo Bogdanov; Anton Kutikhin Journal: Int J Mol Sci Date: 2019-11-15 Impact factor: 5.923
Authors: E R Smith; I Ruderman; S Bruell; K M Nicholls; T D Hewitson; A S Talbot; S G Holt Journal: Osteoporos Int Date: 2022-05-16 Impact factor: 5.071
Authors: Edward R Smith; Tim D Hewitson; Michael M X Cai; Parisa Aghagolzadeh; Matthias Bachtler; Andreas Pasch; Stephen G Holt Journal: Sci Rep Date: 2017-07-18 Impact factor: 4.379