Eric Levesque1,2, Audrey Winter3,4, Zaid Noorah1, Jean-Pierre Daurès3,4, Paul Landais3,5, Cyrille Feray6, Daniel Azoulay2,7. 1. Department of Anaesthesia and Surgical Intensive Care - Liver ICU, AP-HP Henri Mondor Hospital, Créteil, France. 2. INSERM, Unité U955, Créteil, France. 3. UPRES EA 2415 Department of Biostatistics, Clinical Research University Institute, Montpellier University, Montpellier, France. 4. Beau Soleil Clinic, Languedoc Mutualité, Montpellier, France. 5. Department of Biostatistics, Epidemiology, Public Health and Medical Information, University Hospital, Nîmes, France. 6. Department of Hepatology, AP-HP Henri Mondor Hospital, Créteil, France. 7. Digestive Surgery and Liver Transplant Unit, AP-HP Henri Mondor Hospital, Créteil, France.
Abstract
BACKGROUND: Acute-on-chronic liver failure (ACLF) is associated with a significant short-term mortality rate (23%-74%), depending on the number of organ failures. Some patients present with ACLF at the time of liver transplantation (LT). The aim of this study was to assess whether ACLF was also a prognostic factor after LT and, if applicable, to construct a score that could predict 90-day mortality. METHODS: Three hundred and fifty cirrhotic patients, who underwent LT between January 2008 and December 2013, were enrolled. We used ACLF grades according to EASL-CLIF consortium criteria to categorize the cirrhotic patients. A propensity score was applied with an Inverse Probability Treatment Weighting in a Cox model. A predictive score of early mortality after LT was generated. RESULTS: One hundred and forty patients (40%) met the criteria for ACLF. The overall mortality rate at 90 days post-transplant was 10.6% (37/350 patients). ACLF at the time of LT (HR: 5.78 [3.42-9.77], P<.001) was an independent predictor of 90-day mortality. Infection occurring during the month before LT, high recipient age and male recipient, the reason for LT and a female donor were also independent risk factors for early mortality. Using these factors, we have proposed a model to predict 90-day mortality after LT. CONCLUSIONS: LT is feasible in cirrhotic patients with ACLF. However, we have shown that ACLF is a significant and independent predictor of 90-day mortality. We propose a score that can identify candidate cirrhotic patients in whom LT might be associated with futile LT.
BACKGROUND: Acute-on-chronic liver failure (ACLF) is associated with a significant short-term mortality rate (23%-74%), depending on the number of organ failures. Some patients present with ACLF at the time of liver transplantation (LT). The aim of this study was to assess whether ACLF was also a prognostic factor after LT and, if applicable, to construct a score that could predict 90-day mortality. METHODS: Three hundred and fifty cirrhotic patients, who underwent LT between January 2008 and December 2013, were enrolled. We used ACLF grades according to EASL-CLIF consortium criteria to categorize the cirrhotic patients. A propensity score was applied with an Inverse Probability Treatment Weighting in a Cox model. A predictive score of early mortality after LT was generated. RESULTS: One hundred and forty patients (40%) met the criteria for ACLF. The overall mortality rate at 90 days post-transplant was 10.6% (37/350 patients). ACLF at the time of LT (HR: 5.78 [3.42-9.77], P<.001) was an independent predictor of 90-day mortality. Infection occurring during the month before LT, high recipient age and male recipient, the reason for LT and a female donor were also independent risk factors for early mortality. Using these factors, we have proposed a model to predict 90-day mortality after LT. CONCLUSIONS: LT is feasible in cirrhotic patients with ACLF. However, we have shown that ACLF is a significant and independent predictor of 90-day mortality. We propose a score that can identify candidate cirrhotic patients in whom LT might be associated with futile LT.
Authors: A Choudhury; A Jindal; R Maiwall; M K Sharma; B C Sharma; V Pamecha; M Mahtab; S Rahman; Y K Chawla; S Taneja; S S Tan; H Devarbhavi; Z Duan; Chen Yu; Q Ning; Ji Dong Jia; D Amarapurkar; C E Eapen; A Goel; S S Hamid; A S Butt; W Jafri; D J Kim; H Ghazinian; G H Lee; Ajit Sood; L A Lesmana; Z Abbas; G Shiha; D A Payawal; A K Dokmeci; J D Sollano; G Carpio; G K Lau; F Karim; P N Rao; R Moreau; P Jain; P Bhatia; G Kumar; S K Sarin Journal: Hepatol Int Date: 2017-08-30 Impact factor: 6.047
Authors: Abu Bakar H Bhatti; Faisal S Dar; Muhammad O Butt; Eraj Sahaab; Mohammad Salih; Najmul H Shah; Nusrat Y Khan; Haseeb H Zia; Eitzaz U Khan; Nasir A Khan Journal: J Clin Exp Hepatol Date: 2017-11-24