| Literature DB >> 28050627 |
Yu Liu1.
Abstract
Mesoderm posterior 1 is one of earliest markers of the nascent mesoderm. Its best-known function is driving the onset of the cardiovascular system. In the past decade, new evidence supports that Mesp1 acts earlier with greater breadth in cell fate decisions, and through cell-autonomous and cell non-autonomous mechanisms. This review summarizes these new aspects, with an emphasis on the upstream and downstream regulation around Mesp1 and how they may guide cell fate reprogramming.Entities:
Keywords: Cardiomyocyte; Cell fate; Mesoderm; Reprogramming; Stem cell
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Year: 2017 PMID: 28050627 DOI: 10.1007/s00018-016-2448-y
Source DB: PubMed Journal: Cell Mol Life Sci ISSN: 1420-682X Impact factor: 9.261