| Literature DB >> 28049826 |
Yanqiang Wang1,2, Huiling He1,2, Wei Li1,2, John Phay3, Rulong Shen4, Lianbo Yu5,6, Baris Hancioglu6, Albert de la Chapelle7,2.
Abstract
A locus on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcinoma (PTC). The locus also comprises the forkhead box E1 (FOXE1) gene, which is implicated in thyroid development, and a long noncoding RNA (lncRNA) gene, papillary thyroid cancer susceptibility candidate 2 (PTCSC2). How these might interact is not known. Here we report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor. RNA knockdown of FOXE1 in primary thyroid cells profoundly interferes with the p53 pathway. We propose that the interaction between the lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC triggered by rs965513.Entities:
Keywords: MYH9; bidirectional promoter; lncRNA; thyroid cancer; transcriptional regulation
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Year: 2017 PMID： 28049826 PMCID： PMC5255605 DOI： 10.1073/pnas.1619917114
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205