Literature DB >> 28049655

The Role of Aneuploidy in Cancer Evolution.

Laurent Sansregret1, Charles Swanton1,2.   

Abstract

Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow "macroevolutionary" leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.
Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2017        PMID： 28049655      PMCID： PMC5204330          DOI： 10.1101/cshperspect.a028373

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  72 in total

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Journal:  J Mol Med (Berl)       Date:  2018-05-03       Impact factor: 4.599

8.  Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism.

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Journal:  Mol Cell Biol       Date:  2020-05-28       Impact factor: 4.272

9.  Budding yeast CENP-ACse4 interacts with the N-terminus of Sgo1 and regulates its association with centromeric chromatin.

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Journal:  Cell Cycle       Date:  2018-01-02       Impact factor: 4.534

Review 10.  The diverse consequences of aneuploidy.

Authors:  Narendra Kumar Chunduri; Zuzana Storchová
Journal:  Nat Cell Biol       Date:  2019-01-02       Impact factor: 28.824
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