| Literature DB >> 2804684 |
H Kanemitsu1, A Tamura, T Kirino, H Oka, K Sano, T Iwamoto, M Yoshiura, K Iriyama.
Abstract
Uric acid (UA) in the rat brain was measured by HPLC with an electrochemical detector following focal ischemia. At 24 h after the operation, the UA level in the ischemic center was 105.47 +/- 8.39 nmol/g tissue, whereas it was 8.36 +/- 1.86 in the sham-operated group. Allopurinol, xanthine oxidase inhibitor, almost completely inhibited this UA accumulation. These data demonstrate that the UA increase in the ischemic brain is due to the xanthine oxidase reaction.Entities:
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Year: 1989 PMID： 2804684 DOI： 10.1016/0006-8993(89)90786-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252